Integrating experiments and modeling show how a fungal exudate-inspired substrate mixture elicits an emergent growth phenotype and metabolic responses in Pseudomonas putida.

Uncovered how the choice of carbon source influences the stress tolerance, redox balance, and regulatory responses of yeast, which can help provide resilience against scale-up challenges.

Five PNNL innovations earned 2026 R&D 100 Awards for advances in biotechnology, manufacturing, critical minerals, and nuclear security.

Study shows the advantages of top-town proteomics for characterizing histones.

PNNL has developed a next-generation electrical resistivity tomography system for DOE that uses E4D software and AI-enhanced modeling to produce real-time subsurface images that help guide environmental remediation decisions.

A microbial community expresses a phenotype of interest ~20 percent higher than the sum of each member species.

Researchers discovered that a polymer additive promotes smooth, layer-by-layer deposition on metal electrodes by tuning interactions with the substrate.

Anisotropies in surface potential driven by competitive ion adsorption can alter facet selectivity during oriented attachment.

Structural proteomics reveal how cyanobacteria adapt to changing light.

Secretary Wright visited PNNL's campus in Richland, Washington, late last year to meet with innovators in chemistry, biology, computing, and more.

Summarizing the state of designed protein hybrid materials, researchers celebrate both the 50th anniversary of the MRS Bulletin and the 2025 Fred Kavli Distinguished Lecturers in Materials Science, Jim De Yoreo and David Baker.

Researchers use multiomics to confirm role of lipid synthesis during infection, leading to model of how to restrict virus replication.

PNNL researchers Daniel Deng and Yehia Ibrahim join the 2025 class of National Academy of Inventors Fellows.

Specially designed histidine-containing peptoids mimic carbonic anhydrase to accelerate calcite step growth.

Capturing protein structural changes in host cells exposes vulnerabilities exploited by viruses to hijack cellular machinery.

Imaging ice microstructures formed by water freezing with atomic resolution for the first time.

PNNL researchers developed a new computational workflow to study day-to-night gene expression dynamics of cyanobacterium in real time.

In high-entropy oxides, chromium tends to segregate during growth due to oxidation-induced migration of smaller, high-valence cations.

Tailored assemblies mimic natural enzyme activity with significantly higher stability.

Understanding molecular modifications of proteins in the red yeast could help scientists re-engineer the organism’s phenotype.