Effective Density of Agglomerates
At the time ISDD was developed, the effective density of agglomerates was estimated from parameters describing how primary particles packed to form agglomerates. DeLoid and colleagues...read more.
Principles of Use
ISDD applies well established, long-used principles of diffusional and gravitational transport of particles in viscous media to calculate the movement of particles from the media to the bottom of a vessel where cells reside. The net rate of transport...read more.
Dose Translation Across Systems
Applied in conjunction with in vivo dosimetry models such as the Multipath Particle Deposition Model (MPPD), ISDD can be used as the initial step in translating cellular doses of nanoparticles between in vitro and in vivo systems (Teeguarden et al., 2014, below). This application area can grow...read more.