Researchers at PNNL are pursuing new approaches to understand, predict and control the phenome—the collection of biological traits within an organism shaped by its genes and interactions with the environment.

Researchers developed a robust, cost-effective, and easy-to-use cap-based technique for spatial proteome mapping, addressing the lack of accessible proteomics technologies for studying tissue heterogeneity and microenvironments.

Ljiljana Paša-Tolić, a PNNL fellow, is the recipient of the 2024 International Mass Spectrometry Foundation’s Jochen Franzen Award. 

PNNL contributes to a nationwide research consortium investigating the molecular mechanisms triggered by endurance training.

PNNL scientists took thousands of measurements of firefighters in training to learn more about how the body responds to vigorous exercise.

This study profiled the 24-hour rhythmicity in bile salt hydrolase enzyme activity using simple fluorescence assay and the results showed that this rhythmicity is influenced by feeding patterns of the host.

Joshua Adkins and Jamie Lo will lead PMedIC, Pacific Northwest National Laboratory and Oregon Health & Science University’s joint research institute.

New research from PNNL and Washington State University collaborators connects the microbiome in the gut to circadian rhythms, suggesting a role for the microbiome as an internal regulator.

Advanced proteomic analysis tools dig deep into human blood plasma to understand the molecular nature of advanced alcoholic disease.

PNNL Biomedical Scientist Geremy Clair has taken on new roles as an editor for two journals; Frontiers In Cellular And Infection Microbiology and Frontiers In Molecular Biosciences.

Study highlights microbiome’s role in regulating xenobiotic metabolism.

The nested nanoPOTS chip is the next generation of technology developed at PNNL to prepare single cells for proteomics.

Customized molecular tools identify specific microbial functions that are key to healthy people and environments.

PNNL is highlighting scientific and technical experts in the national security domain who were recently promoted to scientist and engineer level 5, one of PNNL’s most senior research roles.

Chemist April Carman was recognized for her career accomplishments with the Professional Achievement Award from the University of Nevada, Reno, College of Science.

Science and engineering solutions helping keep America safe from explosive, radiological, biological and cyber threats.

PNNL commemorates 9/11 and reflects on the 20 years of science and technology produced since to protect against threats and make America safer.

New study elucidates the complex relaxation kinetics of supercooled water using a pulsed laser heating technique at previously inaccessible temperatures.

PNNL's Rich Ozanich, project manager of opioids standards and equipment testing, served on an expert panel about opioid detection as part of a Department of Homeland Security S&T research and development showcase.

PNNL’s infrared pulsed heating technique reveals supercooled water’s weird behavior; opens door to other fluid studies at new Energy Sciences Center.