IDREAM research is conducted in multiple state-of-the-art research facilities within the DOE complex and at partner institutions, including:

• Advanced Light Source (ALS, a DOE user facility at Lawrence Berkeley National Laboratory)
• Advanced Photon Source (APS, a DOE user facility at Argonne National Laboratory)
• Center for Nanoscale Materials (Argonne National Laboratory)
• Electron Photo Induced Chemistry of Surfaces (EPICS) Lab, Georgia Institute of Technology
• Environmental Molecular Sciences Laboratory (EMSL, a DOE user facility at Pacific Northwest National Laboratory)
• European XFEL (EuXFEL) (Germany)
• High Flux Isotope Reactor (Oak Ridge National Laboratory)
• Hyak High Performance Computing Cluster (University of Washington)
• ISIS Neutron and Muon Source (Rutherford Appleton Laboratory in Oxfordshire, UK)
• Kamiak high performance computing (Washington State University)
• Notre Dame Radiation Laboratory (University of Notre Dame and DOE Office of Basic Energy Sciences)
• Physical Sciences Laboratory (Pacific Northwest National Laboratory)
• Radiochemical Processing Laboratory (Pacific Northwest National Laboratory)
• Spallation Neutron Source (Oak Ridge National Laboratory)
• TRIUMF Particle Accelerator Centre (Vancouver, British Columbia, Canada)
• X-ray Facilities (SLAC National Accelerator Laboratory): Linac Coherent Light Source (LCLS) and Stanford Synchrotron Radiation Lightsource (SSRL)
• Wasteform Development Laboratory (Pacific Northwest National Laboratory)