PNNL

Abstract

The NIH Human BioMolecular Atlas Program (HuBMAP) Data Portal (https://portal.hubmapconsortium.org/) serves as a comprehensive repository for multimodal spatial and single-cell data from healthy human tissues. This resource facilitates the NIH HuBMAP consortium's mission to create a widely accessible multi-scale spatial atlas of the healthy human body at single-cell resolution. The portal hosts 9,193 datasets from 25 diff erent data types spanning 29 organ classes across 498 donors, as of June 2026. The portal's infrastructure and user interfaces enable effi cient visualization and analysis directly in web browsers through integrated collaborative Jupyter Workspaces and interactive Vitessce visualizations for over 5,100 non-spatial, 2D, and 3D spatial datasets. Uniform processing pipelines for multiple data types and rigorous quality control processes ensure comparability of results across diff erent laboratories, organs, and donors for large-scale analyses, while externally processed, community-contributed datasets (EPICs) provide complementary perspectives. The portal interface supports both metadata- and data-driven search functionalities, bulk downloads, and integrated data collections, including supplementary data and visualizations for consortium publications.