Post Doctorate Research Associate
Post Doctorate Research Associate

Biography

Dr. Teresa Palazzo is a chemist with the Metabolomics team in PNNL’s Environmental Molecular Sciences Division and the Environmental Molecular Sciences Laboratory (EMSL) user program She has experience in a range of specialties from organic synthesis and quantum chemical modelling, to large scale environmental and human health-driven omics research. Her varied background gives her the ability to approach problems from multiple angles and to communicate between teams of scientists from diverse backgrounds. Palazzo aims to be part of a global team working toward a better society with innovative methods and multidisciplinary collaborations.  

Since joining PNNL, Palazzo has worked primarily with the nuclear magnetic resonance (NMR) capability in EMSL. She has been a part of many NMR-based metabolomics studies including, but not limited to, plant extract, E. coli growth, and fungal culture profiling with a wide variety of aims, and NMR dissolved organic matter and soil organic matter characterization. Additionally, she has helped develop experimental enrichment strategies for O-GlcNAcylated and phosphorylated peptides in a large-scale heart disease study.  

Research Interests 

  • Discrete Fourier transform 

  • Environmental characterization 

  • Metabolomics 

  • NMR spectroscopy 

  • Organic synthesis 

  • Protein chemistry 

  • Soil chemistry 

Education

  • PhD in Chemistry, University of California, Davis 

  • BS in Chemistry, University of Florida 

Awards and Recognitions

Publications

2019 

Tantillo, D. J., J. B. Siegel, C. M. Saunders, T. A. Palazzo, P. P. Painter, T. E. O'Brien, N. N. Nuñez, D. H. Nouri, M. W. Lodewyk, B. M. Hudson, S. R. Hare, and R. L. Davis. 2019. “Computer-Aided Drug Design for Undergraduates.” Journal of Chemical Education 96 (5): 920-925. https://doi.org/10.1021/acs.jchemed.8b00712.  

2018 

Donslund, B. S., N. I. Jessen, G. Bertuzzi, M. Giardinetti, T. A. Palazzo, M. L. Christensen, and K. A. Jørgensen. 2018. “Catalytic Enantioselective [10+4] Cycloadditions.” Angewandte Chemie - International Edition 57 (40): 13182-13186. https://doi.org/10.1002/anie.201807830.  

Donslund, B. S., A. Monleón, T. A. Palazzo, M. L. Christensen, A. Dahlgaard, J. D. Erickson, and K. A. Jørgensen. 2018. “Organocatalytic Enantioselective Higher-Order Cycloadditions of in Situ Generated Amino Isobenzofulvenes.” Angewandte Chemie - International Edition 57 (5): 1246-1250. https://doi.org/10.1002/anie.201710694.  

Næsborg, L., L. A. Leth, G. J. Reyes-Rodríguez, T. A. Palazzo, V. Corti, and K. A. Jørgensen. 2018. “Direct Enantio- and Diastereoselective Oxidative Homocoupling of Aldehydes.” Chemistry - A European Journal 24 (55): 14844-14848. https://doi.org/10.1002/chem.201803506.  

Palazzo, T. A., and K. A. Jørgensen. 2018. “Higher-Order Cycloaddition Reactions: A Computational Perspective.” Tetrahedron 74 (52): 7381-7387. https://doi.org/10.1016/j.tet.2018.11.008.  

Poulsen, P. H., Y. Li, V. H. Lauridsen, D. K. B. Jørgensen, T. A. Palazzo, M. Meazza, and K. A. Jørgensen. 2018. “Organocatalytic Formation of Chiral Trisubstituted Allenes and Chiral Furan Derivatives.” Angewandte Chemie - International Edition 57 (33): 10661-10665. https://doi.org/10.1002/anie.201806238.  

2017 

Lim, N. K., P. Weiss, B. X. Li, C. H. McCulley, S. R. Hare, B. L. Bensema, T. A. Palazzo, D. J. Tantillo, H. Zhang, and F. Gosselin. 2017. “Synthesis of Highly Stereodefined Tetrasubstituted Acyclic All-Carbon Olefins Via a Syn-Elimination Approach.” Organic Letters 19 (22): 6212-6215. https://doi.org/10.1021/acs.orglett.7b03141.  

Mafu, S., P. S. Karunanithi, T. A. Palazzo, B. L. Harrod, S. M. Rodriguez, I. N. Mollhoff, T. E. O'Brien, S. Tong, O. Fiehn, D. J. Tantillo, J. Bohlmann, and P. Zerbe. 2017. “Biosynthesis of the Microtubule-Destabilizing Diterpene Pseudolaric Acid B from Golden Larch Involves an Unusual Diterpene Synthase.” Proceedings of the National Academy of Sciences of the United States of America 114 (5): 974-979. https://doi.org/10.1073/pnas.1612901114.   

Palazzo, T. A., R. Mose, and K. A. Jørgensen. 2017. “Cycloaddition Reactions: Why Is It So Challenging to Move from Six to Ten Electrons?” Angewandte Chemie - International Edition 56 (34): 10033-10038. https://doi.org/10.1002/anie.201701085.  

2016 

Bagdasarian, A. L., H. H. Nguyen, T. A. Palazzo, J. C. Fettinger, M. J. Haddadin, and M. J. Kurth. 2016. “One-Pot Synthesis of Benzo[4,5]Imidazo[2,1-a]Isoquinolines and Isoquinolino[3,4-B]Quinoxalines Via Tandem Cyclization Strategies.” Journal of Organic Chemistry 81 (9): 3924-3928. https://doi.org/10.1021/acs.joc.6b00338.  

Kaseman, D. C., K. M. Oliveira, T. Palazzo, and S. Sen. 2016. “Selenium Chain Length Distribution in GexSe100-x Glasses: Insights from 77Se NMR Spectroscopy and Quantum Chemical Calculations.” Journal of Physical Chemistry B 120 (19): 4513-4521. https://doi.org/10.1021/acs.jpcb.6b02747.  

2015 

Palazzo, T. A., D. Patra, J. S. Yang, E. El Khoury, M. G. Appleton, M. J. Haddadin, D. J. Tantillo, and M. J. Kurth. 2015. “Dibenzonaphthyridinones: Heterocycle-to-Heterocycle Synthetic Strategies and Photophysical Studies.” Organic Letters 17 (23): 5732-5735. https://doi.org/10.1021/acs.orglett.5b02680.  

Palazzo, T. A., T. T. Truong, S. M. T. Wong, E. T. Mack, M. W. Lodewyk, J. G. Harrison, R. A. Gamage, J. B. Siegel, M. J. Kurth, and D. J. Tantillo. 2015. “Reassigning the Structures of Natural Products Using NMR Chemical Shifts Computed with Quantum Mechanics: A Laboratory Exercise.” Journal of Chemical Education 92 (3): 561-566. https://doi.org/10.1021/ed4006584.  

Wedler, H. B., T. A. Palazzo, R. P. Pemberton, C. S. Hamann, M. J. Kurth, and D. J. Tantillo. 2015. “Predicting Hydration Propensities of Biologically Relevant α-Ketoamides.” Bioorganic and Medicinal Chemistry Letters 25 (19): 4153-4157. https://doi.org/10.1016/j.bmcl.2015.08.010.  

2014 

Patra, D., T. A. Palazzo, N. N. Malaeb, M. J. Haddadin, D. J. Tantillo, and M. J. Kurth. 2014. “Cyclic Azacyanines: Experimental and Computational Studies on Spectroscopic Properties and Unique Reactivity.” Journal of Fluorescence 24 (4): 1285-1296. https://doi.org/10.1007/s10895-014-1413-0.  

Roth, A., S. Ott, K. M. Farber, T. A. Palazzo, W. E. Conrad, M. J. Haddadin, D. J. Tantillo, C. E. Cross, J. P. Eiserich, and M. J. Kurth. 2014. “Inhibition of Myeloperoxidase: Evaluation of 2H-Indazoles and 1 H -Indazolones.” Bioorganic and Medicinal Chemistry 22 (22): 6422-6429. https://doi.org/10.1016/j.bmc.2014.09.044.  

2013 

Coffman, K. C., T. A. Palazzo, T. P. Hartley, J. C. Fettinger, D. J. Tantillo, and M. J. Kurth. 2013. “Heterocycle-Heterocycle Strategies: (2-Nitrophenyl)Isoxazole Precursors to 4-Aminoquinolines, 1 H-Indoles, and Quinolin-4(1 H)-Ones.” Organic Letters 15 (8): 2062-2065. https://doi.org/10.1021/ol400787y.  

Nguyen, H. H., T. A. Palazzo, and M. J. Kurth. 2013. “Facile One-Pot Assembly of Imidazotriazolobenzodiazepines Via Indium(III)-Catalyzed Multicomponent Reactions.” Organic Letters 15 (17): 4492-4495. https://doi.org/10.1021/ol402045h.