Five PNNL innovations earned 2026 R&D 100 Awards for advances in biotechnology, manufacturing, critical minerals, and nuclear security.

Study shows the advantages of top-town proteomics for characterizing histones.

Structural proteomics reveal how cyanobacteria adapt to changing light.

Researchers use multiomics to confirm role of lipid synthesis during infection, leading to model of how to restrict virus replication.

Capturing protein structural changes in host cells exposes vulnerabilities exploited by viruses to hijack cellular machinery.

Continued studies will deepen scientists’ understanding of virus-host interactions at the molecular level and also pave the way for developing better drugs to fight emerging viruses.

PNNL scientists use proteomics to unveil how high-density lipoproteins protect against cholesterol accumulation in the artery wall.

Early life exposure to polycyclic aromatic hydrocarbons (PAHs), found in smoke, has been linked to developmental problems. To study the impacts of these pollutants, PAH metabolism in infants and adults were compared.

Discovering and measuring the spatial organization of proteins within cells allows scientists to map complex proteoforms across tissues with near-cellular resolution.

Data reveals mechanisms in our bodies that can help us fight viral pathogenesis.

Scientists screen for nanobodies that recognize wild type and mutant functional proteins to develop a framework to disrupt protein interactions that can cause disease.