MICROBIAL CONSORTIA FOR PROGRAMMABLE OUTPUT VIA PHOTOAUTOTROPH-HETEROTROPH INTERACTIONS
Self-sustained, safe, stable and scalable microbial consortia (S5MicroCon) are described. The microbial consortia are regulated by photoautotroph-heterotroph interactions and RNA aptamer-based gene circuits. A rapid, high-throughput method for engineering RNA aptamer-based gene circuits (e.g. riboswitches) is also described.
Process for Ultra-sensitive Quantification of Target Analytes in Complex Biological Systems (NIH iEdison No. 0685901-11-0007)
Antibody-free processes are disclosed that provide accurate quantification of a wide variety of low-abundance target analytes in complex samples. The processes can employ high-pressure, high-resolution chromatographic separations for analyte enrichment. Intelligent selection of target fractions may be performed via on-line Selected Reaction Monitoring (SRM) or off-line rapid screening of internal standards. Quantification may be performed on individual or multiplexed fractions. Applications include analyses of, e.g., very low abundance proteins or candidate biomarkers in plasma, cell, or tissue samples without the need for affinity-specific reagents.
Transmitters for Animals and Methods for Transmitting from Animals
Animal transmitters are provided that can include: a transducer configured to transmit a signal; process circuitry coupled to the transducer; and an energy harvesting element coupled to the process circuitry. Animals having a transmitter coupled thereto are also provided with the transmitter including an energy harvesting element in operational alignment with the animal's musculoskeletal system. Methods for transmitting the location of an animal are also provided with the methods including: coupling a transmitter powered by an energy harvesting element to the animal; and monitoring the transmissions of the transmitter.
System and Process for Storing Cold Energy
A system and method for storing cold energy are detailed. The system includes a solid refrigerant in a structured form that stores cold energy. Upon deformation, the solid refrigerant transforms into a high energy deformed state from a low energy non-deformed state. In the deformed state, the solid refrigerant stores cold energy that can be released to a desired location upon demand.
DEVICES AND METHODS FOR PERFORMING SHEAR-ASSISTED EXTRUSION AND EXTRUSION PROCESSES
A process for forming extruded products using a device having a scroll face configured to apply a rotational shearing force and an axial extrusion force to the same preselected location on material wherein a combination of the rotational shearing force and the axial extrusion force upon the same location cause a portion of the material to plasticize, flow and recombine in desired configurations. This process provides for a significant number of advantages and industrial applications, including but not limited to extruding tubes used for vehicle components with 50 to 100 percent greater ductility and energy absorption over conventional extrusion technologies, while dramatically reducing manufacturing costs.
CAPTURE AND RELEASE OF ACID GASSES USING TUNABLE ORGANIC SOLVENTS WITH AMINOPYRIDINE
A class of water lean, organic solvents that can bind with various acid gasses to form acid gas bound molecules having a high degree of intramolecular hydrogen bonding which enables their use as regenerable solvents for acid gas capture. Unlike the other devices described in the prior art, the present invention takes advantage of shortened distances between the portions of the molecule that form hydrogen bonds within the structures when loaded with an acid gas so as to create a molecule with a higher internal bonding affinity and a reduced proclivity for agglomeration with other molecules.
IN-SITU FRICTION STIR FORGING OF HIGH STRENGTH ALUMINUM ALLOY AND COMPOSITE GEARS (iEdison No. 0685901-20-0046)
see attached ppt
Method and Apparatus for Enhanced in Vivo MRI Imaging
Techniques described herein combine conventional proton magnetic resonance imaging (MRI) with novel image processing and analysis tools to develop methods for evaluating localized disease state in patients with emphysema, fibrosis, edema, or any combination of these. The imaging techniques employed are spatially sensitive, allowing for more precise diagnosis than spirometry, and do not expose the patient to ionizing radiation. Emphysema will be detected through imaging and analysis that is sensitive to local compliance changes, while fibrosis and edema will be detected and classified through measurements of the distribution, density, and environment of water molecules. It is envisioned that both of these imaging techniques would be employed, if necessary, during a single imaging session. Combination of these techniques into one image/analysis package would provide a powerful MRI tool for disease evaluation and diagnosis. In addition to clinical application, these combined tools would be valuable for large-scale pre-clinical animal studies for assessment of: disease phenotype, severity, progression, and localization; thereby facilitating targeted tissue harvesting, guiding molecular analysis, and preventing blind sacrifice.
SYNTHETIC POLYMERS AND METHODS OF MAKING AND USING THE SAME
Disclosed herein are monomer embodiments that can be used to make polymers, such as homopolymers, heteropolymers, and that can be used in particular embodiments to make sequence-defined polymers. Also disclosed herein are methods of making polymers using such monomer embodiments. Methods of using the polymers disclosed herein also are described.
DEVICES AND METHODS FOR PERFORMING SHEAR-ASSISTED EXTRUSION PROCESSES
A process for forming extruded products using a device having a scroll face configured to apply a rotational shearing force and an axial extrusion force to the same preselected location on material wherein a combination of the rotational shearing force and the axial extrusion force upon the same location cause a portion of the material to plasticize, flow and recombine in desired configurations. This process provides for a significant number of advantages and industrial applications, including but not limited to extruding tubes used for vehicle components with 50 to 100 percent greater ductility and energy absorption over conventional extrusion technologies, while dramatically reducing manufacturing costs.