Techniques described herein combine conventional proton magnetic resonance imaging (MRI) with novel image processing and analysis tools to develop methods for evaluating localized disease state in patients with emphysema, fibrosis, edema, or any combination of these. The imaging techniques employed are spatially sensitive, allowing for more precise diagnosis than spirometry, and do not expose the patient to ionizing radiation. Emphysema will be detected through imaging and analysis that is sensitive to local compliance changes, while fibrosis and edema will be detected and classified through measurements of the distribution, density, and environment of water molecules. It is envisioned that both of these imaging techniques would be employed, if necessary, during a single imaging session. Combination of these techniques into one image/analysis package would provide a powerful MRI tool for disease evaluation and diagnosis. In addition to clinical application, these combined tools would be valuable for large-scale pre-clinical animal studies for assessment of: disease phenotype, severity, progression, and localization; thereby facilitating targeted tissue harvesting, guiding molecular analysis, and preventing blind sacrifice.