ION EXTRACTION AND FOCUSING FROM A FIELD-FREE REGION TO AN ION MOBILITY SPECTROMETER AT ATMOSPHERIC PRESSURE (iEdison No. 0685901-21-0100)
This invention was developed to improve ion movement at atmospheric pressure to enhance ion signal and reduce ion loss for mass spectrometry (MS) and ion mobility spectrometry (IMS). This invention is demonstrated with the atmospheric flow tube (AFT) and involves ion manipulation (e.g., extraction, focusing, and confinement) at atmospheric pressure. There are two components that have been observed to increase ion signal and reduce ion loss. The first is associated with combining the AFT with IMS, in which adjusting electric field gradients between the AFT and IMS improves ion extraction or focuses ions at atmospheric pressure. The second is by modifying the AFT to place a wire down the center of the length of the tube and applying either an AC or a DC voltage to this wire. Placing a square wave voltage on the wire increases ion throughput down the AFT to the detector compared to when the wire is at the same DC potential as the tube. The ability to manipulate ions is more pronounced at slower flows down the tube. Detailed description, figures, and data are provided in the attachment (Figures 1-7).
COLLECTION, RELEASE, AND DETECTION OF ANALYTES WITH POLYMER COMPOSITE SAMPLING MATERIALS
A unique fiber core sampler composition, related systems, and techniques for designing, making, and using the same are described. The sampler is used to interface with existing field instrumentation, such as Ion Mobility Spectrometer (IMS) equipment. Desired sampler characteristics include its: stiffness/flexibility; thermal mass and conductivity; specific heat; trace substance collection/release dependability, sensitivity and repeatability; thickness; reusability; durability; stability for thermal cleaning; and the like. In one form the sampler has a glass fiber core with a thickness less than 0.3 millimeter that is coated with a polymer including one or more of: polymeric organofluorine, polyimide, polyamide, PolyBenzlmidazole (PBI), PolyDiMethylSiloxane (PDMS), sulfonated tetrafluoroethylene (PFSA) and Poly(2,6-diphenyl-p-phenylene Oxide) (PPPO). Multiple polymer coatings with the same or different polymer types may be included, core/substrate surface functionalization utilized, and/or the core/substrate may be at partially filled with thermally conductive particles.
WEARABLE HEALTH MONITORING DEVICE (iEdison No. 0685901-17-0012)
Medical monitor to measure a patients shock index. To date, and to the best of our knowledge, no one has estimated a patients shock using pulseoximeters and ECG sensors.
COLLECTION, RELEASE, AND DETECTION OF ANALYTES WITH POLYMER COMPOSITE SAMPLING MATERIALS (iEdison No. 0685901-14-0005)
A unique fiber core sampler composition, related systems, and techniques for designing, making, and using the same are described. The sampler is used to interface with existing field instrumentation, such as Ion Mobility Spectrometer (IMS) equipment. Desired sampler characteristics include its: stiffness/flexibility; thermal mass and conductivity; specific heat; trace substance collection/release dependability, sensitivity and repeatability; thickness; reusability; durability; stability for thermal cleaning; and the like. In one form the sampler has a glass fiber core with a thickness less than 0.3 millimeter that is coated with a polymer including one or more of: polymeric organofluorine, polyimide, polyamide, PolyBenzlmidazole (PBI), PolyDiMethylSiloxane (PDMS), sulfonated tetrafluoroethylene (PFSA) and Poly(2,6-diphenyl-p-phenylene Oxide) (PPPO). Multiple polymer coatings with the same or different polymer types may be included, core/substrate surface functionalization utilized, and/or the core/substrate may be at partially filled with thermally conductive particles.
ION FUNNEL DEVICE
An ion funnel device is disclosed. A first pair of electrodes is positioned in a first direction. A second pair of electrodes is positioned in a second direction. The device includes an RF voltage source and a DC voltage source. A RF voltage with a superimposed DC voltage gradient is applied to the first pair of electrodes, and a DC voltage gradient is applied to the second pair of electrodes..
System and Method for Anomaly Detection
A method for decomposing a continuous variable into a collection of discrete variables for purposes of statistical modeling.
MICROFLUIDIC ELECTROCHEMICAL DEVICE AND PROCESS FOR CHEMICAL IMAGING AND ELECTROCHEMICAL ANALYSIS AT THE ELECTRODE-LIQUID INTERFACE IN-SITU
A microfluidic electrochemical device and process are detailed that provide chemical imaging and electrochemical analysis under vacuum at the surface of the electrode-sample or electrode-liquid interface in-situ. The electrochemical device allows investigation of various surface layers including diffuse layers at selected depths populated with, e.g., adsorbed molecules in which chemical transformation in electrolyte solutions occurs.
DEVICE AND METHOD TO MANIPULATE IONS IN MULTI-LEVEL SYSTEM (NIH iEdison 0685901-19-0001, Grant No. CA217699)
This invention relates to increasing the ion path length in devices of planar geometry. In these devices, ions are usually manipulated between two of nearly parallel surfaces where the electric field is applied to each surface. The ion path length can be increased by moving ions from the first plane, where the first pair of surfaces manipulate ions, unto a second plane where the second pair of surfaces manipulate surfaces. Ions are urged to move from the first level of ion manipulation to the second level of ion manipulation through a transfer region the contains an orifice through which ions move. The orifice is located orthogonal to the first ion motion. Ions turn from the first direction into the orifice by applying one or more moving or static electric fields that cause ions to move from their primary path in the first level into the orifice and into the second level. A device that contains many levels (more than or equal 2 levels) can be then constructed. We also disclose a method to construct such a device to avoid ion losses and to simplify the assembly of such devices.