Utilizing scintillation nanoparticles as agents for photodynamic therapy for cancer treatment necessitates the use of biocompatible and water soluble nanoparticles. In this article, we report the synthesis and X-ray luminescence of water soluble Ce and Tb doped LaF3 nanoparticles. The nanoparticles are conjugated with folic acid and meso-tetra (o-carboxyphenyl) porphyrin. X-ray luminescence is observed from the nanoparticles in both powder and solution samples. More importantly, singlet oxygen has been detected from the conjugated system following X-ray excitation. These preliminary observations indicate that water-soluble scintillation nanoparticles can be potentially used in photodynamic therapy for deep-tissue cancer treatment.
Revised: April 30, 2008 |
Published: March 15, 2008
Citation
Liu Y., W. Chen, S. Wang, A.G. Joly, S.L. Westcott, and B.K. Woo. 2008.X-Ray Luminescence of LaF3:Tb3+ and LaF3:Ce3+, Tb3+ Water Soluble Nanoparticles.Journal of Applied Physics 103, no. 6:Art. No. 063105.PNNL-SA-56544.doi:10.1063/1.2890148