High throughput liquid chromatograph-mass spectrometry (LC-MS) based proteomics analyses have necessitated development of software to manipulate large volumes of detailed data and produce confident peptide/protein identifications. VIPER unites important data processing steps in a single software package that can be used to visualize peptide mass and LC elution (i.e. retention) time “feature” relationships from individual analyses, match these LC-MS features to accurate mass and time (AMT) tags of peptides previously identified in LC-MS/MS analyses, and to identify and quantify pairs of isotopically labeled peptides.
Revised: March 17, 2011 |
Published: June 1, 2007
Citation
Monroe M.E., N. Tolic, N. Jaitly, J.L. Shaw, J.N. Adkins, and R.D. Smith. 2007.VIPER: an advanced software package to support high-throughput LC-MS peptide identification.Bioinformatics 23, no. 15- August 2007:2021-2023.PNNL-SA-52622.doi:10.1093/bioinformatics/btm281