We present the first results showing the ambient imaging of biological samples in their native environment using nanospray desorption ionization (nanoDESI) mass spectrometry. NanoDESI is an ambient pressure ionization technique that enables precise control of ionization of molecules from substrates. We demonstrate highly sensitive and robust analysis of tissue samples with high spatial resolution (
Revised: January 10, 2012 |
Published: January 3, 2012
Citation
Laskin J., B.S. Heath, P.J. Roach, L.H. Cazares, and O.J. Semmes. 2012.Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry.Analytical Chemistry 84, no. 1:141-148.PNNL-SA-79278.doi:10.1021/ac2021322