A hybrid temperature-responsive hydroxyapatite-poly(N-isopropylacrylamide) (HAP-PNIPAAm) gel has been synthesized by the interpenetration of PNIPAAm into a sintered HAP disk through a radical-initiated polymerization of NIPAAm monomers under N2 atmosphere, and shows sustained positive thermo-responsive drug release profile over a month at PBS buffer.
Revised: July 16, 2020 |
Published: August 21, 2002
Citation
Shin Y., J. Liu, J.H. Chang, and G.J. Exarhos. 2002.Sustained Drug Release on Temperature-Responsive Poly(N-isopropylacrylamide)-Integrated Hydroxyapatite.Chemical Communications 16.PNNL-SA-36662.