February 1, 2003
Journal Article

Probing Single-Molecule Ion Channel Conformational Dynamics Using Fluorescence Imaging, Combined Ultrafast Spectroscopy, and Patch-Clamp Recording

Abstract

Stochastic and inhomogeneous conformational changes often regulate the dynamics of ion channels. Such inhomegeniety makes it difficult, if not impossible; to be characterized not only by ensemble-averaged experiments by also by single-channel patch recording that does not specifically probe the associated conformational changes.

Revised: August 6, 2004 | Published: February 1, 2003

Citation

Harms G.S., G. Orr, and H.P. Lu. 2003. Probing Single-Molecule Ion Channel Conformational Dynamics Using Fluorescence Imaging, Combined Ultrafast Spectroscopy, and Patch-Clamp Recording. Biophysical Journal 84, no. 2 Pt. 2 Supp.:123-A. PNNL-SA-41980.