Probing Ion Channel Conformational Dynamics Using Simultaneous Single-Molecule Ultrafast Spectroscopy and Patch-Champ Electric Recording

March 8, 2004

Journal Article

Probing Ion Channel Conformational Dynamics Using Simultaneous Single-Molecule Ultrafast Spectroscopy and Patch-Champ Electric Recording

Abstract

A new approach to probing single-molecule ion channel kinetics and conformational dynamics, patch-clamp confocal fluorescence microscopy (PCCFM), uses simultaneous ultrafast fluorescence spectroscopy and single-channel electric current recording.

Revised: March 18, 2004 | Published: March 8, 2004

Citation

Harms G.S., G. Orr, and H.P. Lu. 2004. Probing Ion Channel Conformational Dynamics Using Simultaneous Single-Molecule Ultrafast Spectroscopy and Patch-Champ Electric Recording. Applied Physics Letters 84, no. 10:1792-1794. PNNL-SA-40454.