Probing the Energetics of Dissociation of Carbonic Anhydrase-Ligand Complexes in the Gas Phase

June 1, 1999

Journal Article

Probing the Energetics of Dissociation of Carbonic Anhydrase-Ligand Complexes in the Gas Phase

Abstract

This paper describes the use of electrospray ionization-Fourier transform ion cyclotron mass spectrometry (ESI-FTICR-MS) to study the relative stabilities of noncovalent complexes of carbonic anhydrase II (CAII, EC 4.2.1.1) and benzenesulfonamide inhibitors in the gas phase.

Revised: March 23, 2001 | Published: June 1, 1999

Citation

Gao J., Q. Wu, J. Carbeck, Q.P. Lei, R.D. Smith, and G.M. Whitesides. 1999. Probing the Energetics of Dissociation of Carbonic Anhydrase-Ligand Complexes in the Gas Phase. Biophysical Journal 76, no. 6:3253-3260. PNNL-SA-30555.