Synthetic routes to 2-(pyridin-2-yl)-N,N-diphenylacetamide and 2-(6-methylpyridin-2-yl)-N,N-diphenylacetamide are described along with results from the chemical oxidation of these compounds with peracetic acid, m-chloroperbenzoic acid, and OXONE. In each case, oxidations generate four products in varying amounts depending on the oxidant and reaction conditions. Each product has been characterized by spectroscopic methods and the molecular structures of several of the new compounds have been confirmed by X-ray crystallography.
Revised: January 23, 2008 |
Published: November 1, 2007
Citation
Pailloux S., I. Binyamin, L.M. Deck, B.M. Rapko, B.P. Hay, E.N. Duesler, and R.T. Paine. 2007.Oxidation reactivity channels for 2-(pyridin-2-yl)-N,N-diphenylacetamides.Journal of Organic Chemistry 72, no. 4:9195-9202.PNNL-SA-58743.doi:10.1021/jo701408y