Terreic acid is a natural product derived from 6-methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the intermediates and shunt products from the mutant strains, in combined with bioinformatic analyses, allowed us to propose a biosynthetic pathway for terreic acid. Defining the pathway and the genes involved will facilitate the engineering of this molecule with interesting antimicrobial and antitumor bioactivities.
Revised: January 20, 2015 |
Published: September 29, 2014
Citation
Guo C., W. Sun, K.S. Bruno, and C.C. Wang. 2014.Molecular Genetic Characterization of Terreic Acid Pathway in Aspergillus terreus.Organic Letters 16, no. 20:5250–5253.PNNL-SA-102991.doi:10.1021/ol502242a