Simulations of a scalable four compartment reaction model based on the well known epidermal growth factor receptor (EGFR) signal transduction system are used to compare two stochastic algorithms – StochSim and the Gibson-Gillespie. It is concluded that the Gibson-Gillespie is the algorithm of choice for most realistic cases with the possible exception of signal transduction networks characterized by a moderate number (
Revised: December 15, 2005 |
Published: September 15, 2005
Citation
Pettigrew M.F., and H. Resat. 2005.Modeling Signal Transduction Networks: A comparison of two Stochastic Kinetic Simulation Algorithms.Journal of Chemical Physics 123, no. 11:114707-1 - 114707-13.PNNL-SA-39921.doi:10.1063/1.2018641