In this project we proposed to accelerate biomarker discovery and improve disease prediction by combining image and omic data using a single, unified modelling approach. We hypothesized that much richer information could be derived from both the image and omic data when they are analyzed together. Using imaging mass spectrometry (IMS) data collected from mice we fused image and omic data to increase the resolution of the IMS data. Using human data provided to us by Oregon Health and Science University, we developed an initial modeling framework that can increase the accuracy of both imaging and MS datasets.