Liquid chromatography-mass spectrometry (LC-MS)-based quantitative proteomics has become increasingly applied for a broad range of biological applications due to growing capabilities for broad proteome coverage and good accuracy in quantification. Herein, we review the current LC-MS-based quantification methods with respect to their advantages and limitations, and highlight their potential applications.
Revised: August 18, 2011 |
Published: July 22, 2011
Citation
Xie F., T. Liu, W. Qian, V.A. Petyuk, and R.D. Smith. 2011.Liquid Chromatography-Mass Spectrometry-based Quantitative Proteomics.Journal of Biological Chemistry 286, no. 29:25443-25449.PNNL-SA-76123.