Initial Implementation of an Electrodynamic Ion Funnel with Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

January 1, 2000

Journal Article

Initial Implementation of an Electrodynamic Ion Funnel with Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Abstract

In this work, we report on the initial implementation of a newly developed electrodynamic ion funnel in a 3.5 tesla ESI-FTICR mass spectrometer. This initial results show dramatically improved ion transmissionas compared to the conventional capillary-skimmer arrangement. An estimated detection limit of 30 zeptomoles (~18,000 molecules) has been achieved for the analysis of the proteins with molecular weights ranging from 8 to 20 kDa.

Revised: March 26, 2001 | Published: January 1, 2000

Citation

Belov M.E., M.V. Gorshkov, H.R. Udseth, G.A. Anderson, A.V. Tolmachev, D.C. Prior, and R. Harkewicz, et al. 2000. Initial Implementation of an Electrodynamic Ion Funnel with Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Journal of the American Society for Mass Spectrometry 11, no. 1:19-23. PNNL-SA-31459.