A hybrid nanogel is developed based on interpenetrating networks of thermosensitive PNIPAAm gels and tailored nanoporous silica. Sustainable positive thermo-responsive drug release profile is obtained. When the temperature rises, the polymer gel shrinks, squeezing the drug into the porous channels, and at the same time, opening the pore to the outside media. The drug slowly diffuses out of the porous channels. The overall release rate can be adjusted by changing the composition of the nanogel.
Revised: August 26, 2003 |
Published: May 18, 2001
Citation
Shin Y., J.H. Chang, J. Liu, R.E. Williford, Y. Shin, and G.J. Exarhos. 2001.Hybrid Nanogels for Sustainable Positive Thermosensitive Drug Release.Journal of Controlled Release.PNNL-SA-34063.