PNNL

Abstract

The challenges in the analysis of complex biological and environmental samples are open-ended: we want from our separations (and often truly need!) more resolution, greater peak capacity, higher reproducibility, faster speed, and the ability to work with smaller and smaller samples. For detection, and specifically with mass spectrometry (MS), we want greater measurement sensitivity, wider dynamic range, better interface robustness with the separation, more effective compound identification, and improved precision and accuracy of quantification.