Integration of large and diverse biological data sets is a daunting problem facing systems biology researchers. Exploring the complex issues of data validation, integration, and representation, we present a systematic approach for the management and analysis of large biological data sets based on data warehouses. Our system has been implemented in the Bioverse, a framework combining diverse protein information from a variety of knowledge areas such as molecular interactions, pathway localization, protein structure, and protein function.
Revised: June 12, 2009 |
Published: April 20, 2009
Citation
Frazier Z., J.E. McDermott, M. Guerquin, and R. Samudrala. 2009.Computational representation of biological systems. In Computational Systems Biology, Methods in Molecular Biology. 535-550. Totowa, New Jersey:Humana Press.PNNL-SA-56401.