Stereo-selective deuteration has been explored in the 12 base pair DNA Dickerson sequence [d(CGCGAATTCGCG)2] as an approach for improving the accuracy of NMR derived, three-bond vicinal proton-proton coupling constants. The coupling constants are useful for DNA structure determination in restrained molecular dynamics calculations.
Revised: March 3, 2005 |
Published: October 1, 2000
Citation
Yang J., K. McAteer, L.A. Silks, R. Wu, R. Wu, N.G. Isern, and C.J. Unkefer, et al. 2000.A Comprehensive Approach for Accurate Measurement of Proton-Proton Coupling Constants in the Sugar Ring of DNA.Journal of Magnetic Resonance 146, no. 2:260-276.PNNL-SA-32710.