July 26, 2024
Journal Article
Comparison of effects from gamma, e-beam and X-ray radiation on multilayer polymer films used in biopharmaceutical devices by chemometric treatment of spectroscopic data
Abstract
The present study investigated the effects of gamma-ray, electron beam, and X-ray radiation on polymers in EVA/EVOH/EVA multilayer films. Spectroscopic methods, including FTIR and UV–Vis, were employed in conjunction with chemometric treatments such as PCA, SIMPLISMA treatments, and PLS models. The feasibility of dose prediction on multilayer film, given a known dose, is attainable across various irradiation technologies. Both gamma ray and X-ray exhibit comparable effects on the multilayer film, and it is feasible to anticipate the dose released on the film by utilizing UV–Vis spectra or infrared spectra for gamma ray or X-ray of a predetermined dose. Highlights • First time achieving dose modelling using spectrophotometric data. • First time achieving dose modelling using infrared data. • Comparison of gamma, e-beam and X-ray radiation technologies impact on multilayers films.Published: July 26, 2024