Characterization of a Novel Covlent Monoadduct on the RNA Overhang of an RNA-DNA Hybrid Induced by Antitumor Antibiotic Neocarzinostatin

February 10, 1998

Journal Article

Characterization of a Novel Covlent Monoadduct on the RNA Overhang of an RNA-DNA Hybrid Induced by Antitumor Antibiotic Neocarzinostatin

Abstract

Neocarzinostatin chromophore (NCS-chrom) has been found previously to induce thiol-dependent abasic site formation and cleavage on the RNA strand of RNA - DNA hybrids.

Revised: April 30, 2019 | Published: February 10, 1998

Citation

Zheng P., C. Liu, Z. Xi, R.D. Smith, and I. Goldberg. 1998. Characterization of a Novel Covlent Monoadduct on the RNA Overhang of an RNA-DNA Hybrid Induced by Antitumor Antibiotic Neocarzinostatin. Biochemistry 37, no. 6:1706-1713. PNNL-SA-30185. doi:10.1021/bi972659w