Biomedical Scientist
Biomedical Scientist

Biography

Sneha Couvillion’s current research focuses on deciphering microbial metabolic activity and interactions using a combination of powerful mass-spectrometry (MS)-based omics methods (metabolomics, lipidomics, and proteomics) in a variety of environmental and human health related projects.

Disciplines and Skills

  • Metabolomics
  • Lipidomics
  • Proteomics
  • Microbial communities
  • Soil
  • Human health
  • MS
  • Omics

Education

  • PhD in Chemical and Biomolecular Engineering, University of Notre Dame
  • MS in Chemical and Biomolecular Engineering, University of Notre Dame
  • MT in Chemical Engineering, Jawaharlal Nehru Technological University
  • BT in Chemical Engineering, Jawaharlal Nehru Technological University

Publications

View complete list of publications on Google Scholar

2021

  • Cao X, X Pan, SP Couvillion, T Zhang, C Tamez, LM Bramer, JC White, W-J Qian, BD Thrall, KW Ng, X Hu, P Demokritou. "Fate, cytotoxicity and cellular metabolomic impact of ingested nanoscale carbon dots using simulated digestion and a triculture small intestinal epithelial model." NanoImpact 23: 100349 (2021). doi: 10.1016/j.impact.2021.100349 
  • Xu C, SP Couvillion, RL Sontag, NG Isern, Y Maezato, SR Lindemann, TR Chowdhury, R Zhao, BR Morton, RK Chu, RJ Moore, JK Jansson, VL Bailey, PJ Mouser, MF Romine, JF Fredrickson, TO Metz. "MetFish: a Metabolomics Pipeline for Studying Microbial Communities in Chemically Extreme Environments." mSystems 6, no. 3:e01058-20 (2021). doi: 10.1128/mSystems.01058-20
  • Zamith-Miranda D, RP da Silva, SP Couvillion, EL Bredeweg, MC Burnet, C Coelho, E Camacho, L Nimrichter, R Puccia, IC Almeida, A Casadevall, ML Rodrigues, LR Alves, JD Nosanchuk, ES Nakayasu. "Omics approaches for understanding biogenesis, composition and functions of fungal extracellular vesicles." Frontiers in Genetics 12:641 (2021). doi: 10.3389/fgene.2021.648524
  • Wang L-B, A Karpova, MA Gritsenko, JE Kyle, S Cao, Y Li, D Rykunov, A Colaprico, JH Rothstein, R Hong, V Stathias, M Cornwell, F Petralia, Y Wu, B Reva, K Krug, P Pugliese, E Kawaler, LK Olsen, W-W Liang, X Song, Y Dou, MC Wendl, W Caravan, W Liu, DC Zhou, J Ji, C-F Tsai, VA Petyuk, J Moon, W Ma, RK Chu, KK Weitz, RJ Moore, ME Monroe, R Zhao, X Yang, S Yoo, A Krek, A Demopoulos, H Zhu, MA Wyczalkowski, JF McMichael, BL Henderson, CM Lindgren, H Boekweg, S Lu, J Baral, L Yao, KG Stratton, LM Bramer, E Zink, SP Couvillion, KJ Bloodsworth, S Satpathy, W Sieh, SM Boca, S Schürer, F Chen, M Wiznerowicz, KA Ketchum, ES Boja, CR Kinsinger, AI Robles, T Hiltke, M Thiagarajan, AI Nesvizhskii, B Zhang, DR Mani, M Ceccarelli, XS Chen, SL Cottingham, QK Li, AH Kim, D Fenyö, KV Ruggles, H Rodriguez, M Mesri, SH Payne, AC Resnick, P Wang, RD Smith, A Iavarone, MG Chheda, JS Barnholtz-Sloan, KD Rodland, T Liu, L Ding, A Agarwal, M Amin, E An, ML Anderson, DW Andrews, T Bauer, C Birger, MJ Birrer, L Blumenberg, WE Bocik, U Borate, M Borucki, MC Burke, S Cai, AP Calinawan, SA Carr, S Cerda, D W Chan, A Charamut, LS Chen, D Chesla, AM Chinnaiyan, S Chowdhury, MP Cieślik, DJ Clark, H Culpepper, T Czernicki, F D'Angelo, J Day, S De Young, E Demir, SM Dhanasekaran, R Dhir, MJ Domagalski, B Druker, E Duffy, M Dyer, NJ Edwards, R Edwards, K Elburn, M J Ellis, J Eschbacher, A Francis, S Gabriel, N Gabrovski, L Garofano, G Getz, MA Gillette, AK Godwin, D Golbin, Z Hanhan, LI Hannick, P Hariharan, B Hindenach, KA Hoadley, G Hostetter, C Huang, E Jaehnig, SD Jewell, N Ji, CD Jones, A Karz. "Proteogenomic and metabolomic characterization of human glioblastoma." Cancer Cell 39, no. 4:509-528.e20 (2021). doi: 10.1016/j.ccell.2021.01.006
  • AA Aksenov, I Laponogov, Z Zhang, SLF Doran, I Belluomo, D Veselkov, Wt Bittremieux, LF Nothias, M Nothias-Esposito, KN Maloney, BB Misra, AV Melnik, A Smirnov, X Du, KL Jones, K Dorrestein, M Panitchpakdi, M Ernst, JJJ van der Hooft, Ml Gonzalez, C Carazzone, A Amézquita, C Callewaert, JT Morton, RA Quinn, A Bouslimani, AA Orio, D Petras, AM Smania, SP Couvillion, MC Burnet, CD Nicora, E Zink, TO Metz, V Artaev, E Humston-Fulmer, R Gregor, MM Meijler, Ik Mizrahi, S Eyal, B Anderson, R Dutton, R Lugan, P Le Boulch, Y Guitton, S Prevost, A Poirier, G Dervilly, B Le Bizec, A Fait, NS Persi, C Song, K Gashu, R Coras, M Guma, J Manasson, JU Scher, DK Barupal, S Alseekh, AR Fernie, R Mirnezami, V Vasiliou, R Schmid, RS Borisov, LN Kulikova, R Knight, M Wang, GB Hanna, PC Dorrestein, K Veselkov. "Auto-deconvolution and molecular networking of gas chromatography–mass spectrometry data." Nature Biotechnology 39, no. 2:169-173 (2021). doi: 10.1038/s41587-020-0700-3

2020

  • Couvillion SP, Agrawal N, Colby SM, Brandvold KR, Metz TO. “Who Is Metabolizing What? Discovering Novel Biomolecules in the Microbiome and the Organisms Who Make Them.” Frontiers in Cellular and Infection Microbiology 10, 388. (2020). https://doi.org/10.3389/fcimb.2020.00388
  • Cleare L.G., D. Zamith-Miranda, H.M. Heyman, S.P. Couvillion, L. Nimrichter, M.L. Rodrigues, and E.S. Nakayasu, et al. 2020. "Media Matters! Alterations in the loading and release of Histoplasma capsulatum extracellular vesicles in response to different nutritional milieus." Cellular Microbiology 22, no. 9:Article No. e13217. PNNL-SA-151908. doi:10.1111/cmi.13217
  • Khare S., G.M. Deloid, R.M. Molina, K. Gokulan, S.P. Couvillion, K.J. Bloodsworth, and E.K. Eder, et al. 2020. "Effects of ingested nanocellulose on intestinal microbiota and homeostasis in Wistar Han rats." NanoImpact 18. PNNL-SA-149247. doi:10.1016/j.impact.2020.100216

2019

  • Zamith-Miranda D., H.M. Heyman, L.G. Cleare, S.P. Couvillion, G. Clair, E.L. Bredeweg, and A. Gacser, et al. 2019. "Multi-omics signature of Candida Auris, an emerging and multidrug-resistant pathogen." mSystems 4, no. 4:e00257-19. PNNL-SA-140174. doi:10.1128/mSystems.00257-19
  • Couvillion, Sneha P., et al. "New mass spectrometry technologies contributing towards comprehensive and high throughput omics analyses of single cells." Analyst 144.3 (2019): 794-807. 10.1039/C8AN01574K