Biomedical Scientist
Biomedical Scientist

Biography

Priscila Lalli is a biomedical scientist with the Biosample Pipeline team in the Biological Sciences Division at Pacific Northwest National Laboratory (PNNL). Lalli is responsible for maintaining and advancing liquid chromatography mass spectrometry and liquid chromatography ion mobility mass spectrometry pipelines for metabolomics.

Lalli has more than 10 years’ experience in analysis of small molecules by ion mobility and mass spectrometry, including different mass analyzers (time-of-flight, quadrupole, Orbitrap, Fourier-transform ion cyclotron resonance) and ionization sources. She is experienced in method development, data collection, analysis, and interpretation.

She obtained her PhD in chemistry from the State University of Campinas with Professor Marcos Eberlin at the ThoMSon Mass Spectrometry Laboratory and then completed a postdoctoral appointment at the National High Magnetic Field Laboratory with Professor Alan Marshall. Before joining PNNL, Lalli was a research scientist at the National High Magnetic Field Laboratory studying petroleum heavy ends (high boiling point and polar species) by Fourier-transform ion cyclotron resonance/mass spectrometry and ion mobility spectrometry/mass spectrometry.

Research Interest

  • Metabolomics
  • Mass Spectrometry
  • Ion Mobility

Education

  • PhD in Chemistry, State University of Campinas, Brazil
  • MS in Chemistry, State University of Campinas, Brazil
  • BS in Chemistry, State University of Campinas, Brazil

Publications

2017

  • Lalli, P.M.; Jarvis, J.M.; Marshall, A.G. and Rodgers, R.P. “Functional Isomers in Petroleum Emulsion Interfacial Material Revealed by Ion Mobility Mass Spectrometry and Collision-Induced Dissociation” Energy & Fuels 2017, 31, 1, 311-318.
  • Ligiero, L.M.; Dicharry, C.; Passade-Boupat, N.; Bouyssiere, B.; Lalli, P.M.; Rodgers, R.P.; Barrère-Mangote, C.; Giusti, P. and Bouriat, P. “Characterization of Crude Oil Interfacial Material Isolated by the Wet Silica Method. Part 2: Dilatational and Shear Interfacial Properties” Energy & Fuels 2017, 31, 2, 1072-1081.
  • Ligiero, L.M.; Bouriat, P.; Dicharry, C.; Passade-Boupat, N.; Lalli, P.M.; Rodgers, R.P.; Barrère-Mangote, C.; Giusti, P. and Bouyssiere, B. “Characterization of Crude Oil Interfacial Material Isolated by the Wet Silica Method. Part 1: Gel Permeation Chromatography Inductively Coupled Plasma High-Resolution Mass Spectrometry Analysis” Energy & Fuels 2017, 31, 2, 1065-1071.

2016

  • Farenc, M.; Corilo, Y.E; Lalli, P.M.; Riches, E.; Rodgers, R.P.; Afonso, C.; and Giusti, P. “Comparison of Atmospheric Pressure Ionization for the Analysis of Heavy Petroleum Fractions with Ion Mobility-Mass Spectrometry” Energy & Fuels 2016, 30(11), 8896-8903.

2015

  • Lalli, P.M.; Corilo, Y.E.; Rowland, S.M.; Marshall, A.G.; Rodgers, R.P. “Isomeric Separation and Structural Characterization of Acids in Petroleum by Ion Mobility Mass Spectrometry” Energy & Fuels 2015, 29(6), 3626-3633.
  • Rodrigues, T.S.; Machado, F.; Lalli, P.M.; Eberlin, M.N.; Neto, B.A.D. “Styrene polymerization efficiently catalyzed by iron-containing imidazolium-based ionic liquids: Reaction mechanism and enhanced ionic liquid effect” Catal. Commun. 2015, 63, 66-73.

2014

  • Rodrigues, T.S.; Silva, V.H.C.; Lalli, P.M.; Oliveira, H.C.B.; Silva, W.A.; Coelho, F.; Eberlin, M.N.; Neto, B.A.D. “Morita-Baylis-Hillman reaction: ESI-MS(/MS) investigation with charge tags and ionic liquid effect origin revealed by DFT calculations” J. Org. Chem. 2014, 79, 5239-5248.

2013

  • Lalli, P.M.; Corilo, Y.E.; Fasciotti, M.; Riccio, M.F.; Sa, G.F.; Daroda, R.J.; Souza, G.H.M.F.; McCullagh, M.; Bartberger, M.D.; Eberlin, M.N.; Campuzano, I.D.G. “Baseline resolution of isomers by traveling wave ion mobility mass spectrometry: investigating the effects of polarizable drift gases and ionic charge distribution” J. Mass Spectrom. 2013, 48, 989-997.
  • Fasciotti, M.; Lalli, P.M.; Klitzke, C.F.; Corilo, Y.E.; Pudenzi, M.A.; Pereira, R.C.L.; Bastos, W.; Daroda, R.J.; Eberlin, M.N. “Petroleomics by traveling wave ion mobility-mass spectrometry using CO2 as a drift gas” Energy & Fuels 2013, 27, 7277-7286.
  • Fasciotti, M.; Lalli, P.M.; Heerdt, G.; Steffen, R.A.; Corilo, Y.E.; Sa, G.F.; Daroda, R.J.; Reis, F.A.M.; Morgon, N.H.; Pereira, R.C.L.; Eberlin, M.N.; Klitzke, C.F. “Structure-drift time relationships in ion mobility mass spectrometry” Int. J. Ion Mobil. Spec. 2013, 16, 117-132.
  • Neto, B.A.D.; Viana, B.F.L.; Rodrigues, T.S.; Lalli, P.M.; Eberlin, M.N. Silva, W.A.; Oliveira, H.B.; Gatto, C.C. “Condensed, solution and gas-phase behaviour of mono- and dinuclear 2,6-diacetylpyridine (dap) hydrazone copper complexes probed by X-ray, mass spectrometry and theoretical calculations” Dalton Trans. 2013, 42, 11497-11506.

2012

  • Lalli, P.M.; Iglesias, B.A.; Toma, H.E.; Sa, G.F.; Daroda, R.J.; Silva Filho, J.C.; Szulejko, J.E.; Araki, K.; Eberlin, M.N. “Protomers: formation, separation and characterization via travelling wave ion mobility mass spectrometry” J. Mass Spectrom. 2012, 47, 712 - 719.
  • Fasciotti, M.; Sanvido, G.B.; Santos, V.G.; Lalli, P.M.; McCullagh, M.; Sa, G.F.; Daroda, R.J.; Peter, M.G.; Eberlin, M.N. “Separation of isomeric disaccharides by traveling wave ion mobility mass spectrometry using CO2 as drift gas” J. Mass Spectrom. 2012, 47, 1643-1647.
  • Santos, J.J.; Toma, S.H.; Lalli, P.M.; Riccio, M.F.; Eberlin, M.N.; Toma, H.E.; Araki, K. “Exploring the coordination chemistry of isomerizable terpyridine derivatives for successful analyses of cis and trans isomers by travelling wave ion mobility mass spectrometry” Analyst 2012, 137, 4045 - 4051.
  • Romão, W.; Vaz, B.G.; Lalli, P.M.; Bueno, M.I.M.S.; Correa, D.N.; Telles, V.L.C.N.; Castro, E.V.R.; Eberlin, M.N. “Analyzing Brazilian Vehicle Documents for Authenticity by Easy Ambient Sonic-Spray Ionization Mass Spectrometry.” J. Forensic Sc. 2012, 57, 539 – 543.
  • Lalli, P.M.; Iglesias, B.A.; Deda, D.K.; Toma, H.E.; Sa, G.F.; Daroda, R.J.; Araki, K.; Eberlin, M.N.
  • “Resolution of isomeric multi-ruthenated porphyrins by travelling wave ion mobility mass spectrometry” Rapid Commun. Mass Spectrom. 2012, 26, 263 – 268.
  • Lalli, P.M.; Rodrigues, T.S.; Arouca, A.M.; Eberlin, M.N.; Neto, B.A.D. “N-heterocyclic carbenes with negative-charge tags: direct sampling from ionic liquid solutions” RSC Advances 2012, 2, 3201 – 3203.

2011

  • Lalli, P.M.; Corilo, Y. E.; Sa, G.F.; Daroda, R.J.; Souza, V.; Souza, G.H.M.F.; Campuzano, I.; Ebeling, G.; Dupont, J.; Eberlin, M.N. “Intrinsic Mobility of Gaseous Cationic and Anionic Aggregates of Ionic Liquids.” ChemPhysChem 2011, 12, 1444 – 1447.
  • Oliveira, F.F.D.; Santos, M.R.; Lalli, P.M.; Schmidt, E.M.; Bakuzis, P.; Lapis, A.A.M.; Monteiro, A.L.; Eberlin, M.N.; Neto, B.A.D. “Charge-Tagged Acetate Ligands As Mass Spectrometry Probes for Metal Complexes Investigations: Applications in Suzuki and Heck Phosphine-Free Reactions” J. Org. Chem. 2011, 76, 10140 –10147.
  • Romão, W.; Lalli, P.M.; Franco, M.F.; Sanvido, G.; Schwab, N.V.; Lanaro, R.; Costa, J.L.; Sabino, B.D.; Bueno, M.I.M.S.; Sa, G.F.; Daroda, R.J.; Souza, V.; Eberlin, M.N. “Chemical profile of meta-chlorophenylpiperazine (m-CPP) in ecstasy tablets by easy ambient sonic-spray ionization, X-ray fluorescence, ion mobility mass spectrometry and NMR” Anal. Bioanal. Chem. 2011, 400, 3053 – 3064.

2010

  • Alberici, R.M.; Simas, R.C.; Sanvido, G.B.; Romão, W.; Lalli, P.M.; Benassi, M.; Cunha, I.B.S.; Eberlin, M.N. “Ambient mass spectrometry: bringing MS into the ‘real world.’” Anal. Bioanal. Chem. 2010, 398, 265 - 294.
  • Lalli, P.M.; Sanvido, G.B.; Garcia, J.S.; Haddad, R.; Cosso, R.G.; Maia, D.R.J.; Zacca, J.J.; Maldaner, A.O.; Eberlin, M.N. “Fingerprinting and aging of ink by easy ambient sonic-spray ionization mass spectrometry.” Analyst 2010, 135, 745 - 750.
  • Lalli, P.M.; Corilo, Y.E.; Abdelnur, P.V.; Eberlin, M.N.; Laali, K.K. “Intrinsic acidity and electrophilicity of gaseous propargyl/allenyl carbocations.” Org. Biomol. Chem. 2010, 8, 2580 - 2585.