Chemist
Chemist

Biography

Dr. David Hoyt is a chemist in PNNL’s Environmental and Molecular Sciences Division, supporting the Environmental Molecular Sciences Laboratory (EMSL) user program. Hoyt has over 30 years of experience with research related to nuclear magnetic resonance (NMR) and other forms of spectroscopy. His research focus has been on the structure and dynamics of bio-complexes and metabolite identification via NMR. More recently, his interests have broadened to include biogeochemistry and NMR specialty-probe development projects. Hoyt has co-authored peer-reviewed publications in Nature Microbiology, Nature Communications, Nature Structural Biology, PNAS, Cell, ISME, Molecular Cell, JACS, Biochemistry, and Journal of Magnetic Resonance.  

For 10 years, Hoyt served in EMSL management and for over 25 years in technical support of the EMSL user program—providing research collaboration in high-field liquids NMR with structural biology and metabolomics applications, as well as in situ chemistry projects.  

Hoyt was responsible to site and develop ~$12 million in new American Reinvestment and Recovery Act funded magnetic resonance systems between June 2009 and November 2011. He has also served as project manager of several recent procurements for PNNL. From 2002 to present he worked to site and develop over $40 million in NMR and electron paramagnetic resonance equipment with EMSL operations. This work included enhancements to in situ controlled-environment NMR and metabolomics capabilities. His leadership on the R&D team for high-temperature and high-pressure NMR rotor capability development for in situ measurements of mixed-phased chemistry and biologics has recently led to licensing by Revolution NMR LLC (Fort Collins, CO). His present interests now include advancing PNNL and EMSL science through further work developing and participating in research and R&D of integrated capabilities related to biological, environmental, and molecular-interface contexts.

 

Research Interest

  • NMR 
  • Metabolomics 
  • NMR technology development for controlled sample environments to aid in situ measurements 
  • Supercritical fluid/mineral/microbe nteractions 
  • Bio-oils and biofuels 
  • Structural basis for protein-protein interactions 
  • Other spectroscopies: CD, fluorescence 

Education

  • PhD in Biochemistry, University of Texas Southwestern Medical Center, 1990 
  • MA in Biochemistry, University of Delaware, 1987 
  • BS in Chemistry, Millersville University, 1983 

Affiliations and Professional Service

  • Past Reviewer, Small Business Innovation Research and Small Business Technology Transfer Program, Office of Science, U.S. Department of Energy  
  • Past Reviewer, Chemical Research Instrumentation and Facility, National Science Foundation  
  • Past Reviewer, Natural Sciences and Engineering Research Council of Canada  
  • Past Reviewer, Computing in Science & Engineering  
  • American Chemical Society 
  • American Association for the Advancement of Science 
  • American Geophysical Union 
  • American Society for Microbiology 
  • Metabolomics Society 

Awards and Recognitions

  • Best Paper Award, Earth and Biological Sciences Directorate (2019, 2017) 
  • Top 100 Stories of 2016 for "Digging Deep for New Bacteria," related to 2016 publication in Nature Microbiology. Discover Magazine (2016) 
  • R&D100 Award for “Pressurized Magic Angle Spinning, Technology for Nuclear Magnetic Resonance Spectroscopy." (2015) 
  • Individual and Team Outstanding Performance Awards, PNNL (1999 – 2011)  
  • Director Award for Outstanding Contributions, EMSL (2004) 
  • Director Award for Laboratory Equipment Distinguished Manager, EMSL (2004) 

Patents

  • ED Walter, JA Sears, HS Mehta, DW Hoyt. 2020. “Snap-in Bushings and Process for High-Pressure and/or High Temperature Magic Angle Spinning Nuclear Magnetic Resonance” US Patent No. 10,550,889. 
  • JZ Hu, JA Sears, DW Hoyt, HS Mehta, CHF Peden. 2015. “Magic Angle Spinning Nuclear Magnetic Resonance Apparatus and Process for High-Resolution In Situ Investigations.” U.S. Patent No. 9,194,920. 
  • DW Hoyt, JA. Sears, RVF Turcu, KM Rosso, and JZ Hu. 2014. “Devices and Process for High-Pressure Magic Angle Spinning Nuclear Magnetic Resonance.” U.S. Patent No. 8,692,548.  
  • JZ Hu, JA Sears, DW Hoyt, and RA Wind. 2009. “Discrete Magic Angle Turning System, Apparatus and Process for In Situ Magnetic Resonance Spectroscopy and Imaging.” U.S. Patent No. 7,535,224.   
  • ED Walter, JA Sears, HS Mehta, DW Hoyt. Filed June 1, 2017. “Snap-in Bushings and Process for High-Pressure and/or High Temperature Magic Angle Spinning Nuclear Magnetic Resonance.” German Patent Pending – DE201710112768  (IPID-30618-E-DE).  
  • ED Walter, JA Sears, HS Mehta, DW Hoyt. Filed July 1, 2017. “Snap-in Bushings and Process for High-Pressure and/or High Temperature Magic Angle Spinning Nuclear Magnetic Resonance” Japan Patent Pending - JP2017144364A (IPID-30618-E-JP). 

Publications

2025

  • Mcgivern B.B., J. Ellenbogen, D.W. Hoyt, J. Bouranis, B. Stemple, R. Daly, and S. Bosman, et al. 2025. "Polyphenol rewiring of the microbiome reduces methane emissions." The ISME Journal 19, no. 1:Art. No. wraf108. PNNL-SA-212383. doi:10.1093/ismejo/wraf108

2024

  • Ellenbogen J., M.A. Borton, B.B. Mcgivern, D. Cronin, D.W. Hoyt, V. Freire-Zapata, and C.K. Mccalley, et al. 2024. "Methylotrophy in the Mire: direct and indirect routes for methane production in thawing permafrost." mSystems 9, no. 1:Art. No. e00698-23. PNNL-SA-189609. doi:10.1128/msystems.00698-23
  • Kuri Cruz A., M. Alves, T. Andresson, A.L. Bayless, K.J. Bloodsworth, J.A. Bowden, and K. Bullock, et al. 2024. "Multiplatform metabolomic interlaboratory study of a whole human stool candidate reference material from omnivore and vegan donors." Metabolomics 20. PNNL-SA-198688. doi:10.1007/s11306-024-02185-0
  • Rajakaruna S., G. Makke, N. Graf-Grachet, C. Ayala-Ortiz, J. Bouranis, D.W. Hoyt, and J.G. Toyoda, et al. 2024. "Adding labile carbon to peatland soils triggers deep carbon breakdown." Communications Earth & Environment 5, no. _:Art. No. 792. PNNL-SA-199291. doi:10.1038/s43247-024-01954-y
  • Ugwuodo C.J., F. Colosimo, J. Adhikari, S.O. Purvine, E.K. Eder, D.W. Hoyt, and S.A. Wright, et al. 2024. "Aromatic amino acid metabolism and active transport regulation are implicated in microbial persistence in fractured shale reservoirs." ISME Communications 4, no. 1:ycae149. PNNL-SA-202989. doi:10.1093/ismeco/ycae149

2023

  • Borton M., M. Shaffer, D.W. Hoyt, R. Jiang, J. Ellenbogen, S.O. Purvine, and C.D. Nicora, et al. 2023. "Targeted curation of the gut microbial gene content modulating human cardiovascular disease." mBio 14, no. 5:e01511-23. PNNL-SA-161876. doi:10.1128/mbio.01511-23
  • Hildebrand G., L.K. Honeker, V. Freire-Zapata, C.O. Ayala-Ortiz, S. Rajakaruna, J.D. Fudyma, and E. Daber, et al. 2023. "Uncovering the Dominant Role of Root Metabolism in Shaping Rhizosphere Metabolome under Drought in Tropical Rainforest Plants." Science of the Total Environment 899. PNNL-SA-176254. doi:10.1016/j.scitotenv.2023.165689
  • Honeker L.K., G. Pugiliese, J. Ingrisch, J.D. Fudyma, J. Gil Loaiza, E.M. Carpenter, and E. Singer, et al. 2023. "Drought re-routes soil microbial carbon metabolism towards emission of volatile metabolites in an artificial tropical rainforest." Nature Microbiology 8, no. 8:1440-1494. PNNL-SA-176253. doi:10.1038/s41564-023-01432-9
  • Kinmonth-Schultz H.A., S. Walker, A.K. Bingol, D.W. Hoyt, Y. Kim, L. Markillie, and H.D. Mitchell, et al. 2023. "Oligosaccharide production and signaling correlate with delayed flowering in an Arabidopsis genotype grown and selected in high [CO2]." PLoS One 18, no. 12:Art. No. e0287943. PNNL-SA-187156. doi:10.1371/journal.pone.0287943
  • Krause S.J., J. Liu, D.J. Yousavich, D. Robinson, D.W. Hoyt, Q. Qin, and F. Wenzhoefer, et al. 2023. "Evidence of cryptic methane cycling and non-methanogenic methylamine consumption in the sulfate-reducing zone of sediment in the Santa Barbara Basin, California." Biogeosciences 20, no. 20:4377-4390. PNNL-SA-189610. doi:10.5194/bg-20-4377-2023
  • Mcdaniel E.A., M. Scarborough, D. Mulat, X. Lin, P. Sampara, H.M. Olson, and R.P. Young, et al. 2023. "Diverse electron carriers drive syntrophic interactions in an enriched anaerobic acetate-oxidizing consortium." The ISME Journal 17, no. 12:2326-2339. PNNL-SA-186718. doi:10.1038/s41396-023-01542-6

2022

  • Honeker L.K., G. Hildebrand, J.D. Fudyma, E. Daber, D.W. Hoyt, S.E. Flowers, and J. Gil Loaiza, et al. 2022. "Elucidating Drought-Tolerance Mechanisms in Plant Roots through 1H NMR Metabolomics in Parallel with MALDI-MS, and NanoSIMS Imaging Techniques." Environmental Science & Technology 56, no. 3:2021-2032. PNNL-SA-163445. doi:10.1021/acs.est.1c06772
  • Rubinstein R.L., M. Borton, H. Zhou, M. Shaffer, D.W. Hoyt, J.C. Stegen, and C. Henry, et al. 2022. "ORT: A workflow linking genome-scale metabolic models with reactive transport codes." Bioinformatics 38, no. 3:778-784. PNNL-SA-160676. doi:10.1093/bioinformatics/btab753

2021

  • Boiteau R.M., L. Markillie, D.W. Hoyt, D. Hu, R.K. Chu, H.D. Mitchell, and L. Pasa-Tolic, et al. 2021. "Metabolic interactions between Brachypodium and Pseudomonas fluorescens under 1 controlled iron-limited conditions." mSystems 6, no. 1:e00580-20. PNNL-SA-159673. doi:10.1128/mSystems.00580-20
  • Boiteau R.M., L. Markillie, H.D. Mitchell, D. Hu, R.K. Chu, D.W. Hoyt, and L. Pasa Tolic, et al. 2021. "Metabolic Interactions between Brachypodium and Pseudomonas fluorescens under Controlled Iron-Limited Conditions." mSystems 6, no. 1:e00580-20. PNNL-SA-147916. doi:10.1128/mSystems.00580-20
  • Del Cerro C., E. Erickson, T. Dong, A.R. Wong, E. Eder, S.O. Purvine, and H.D. Mitchell, et al. 2021. "Intracellular pathways for lignin catabolism in white-rot fungi." Proceedings of the National Academy of Sciences (PNAS) 118, no. 9:e2017381118. PNNL-SA-155713. doi:10.1073/pnas.2017381118
  • Fudyma J.D., J.G. Toyoda, R.K. Chu, K.K. Weitz, H.M. Heyman, E. Eder, and D.W. Hoyt, et al. 2021. "Sequential abiotic-biotic processes drive organic carbon transformation in peat bogs." Journal of Geophysical Research: Biogeosciences 126, no. 2:e2020JG006079. PNNL-SA-160453. doi:10.1029/2020JG006079
  • McGivern B.B., M. Tfaily, M. Borton, S. Kosina, R. Daly, C.D. Nicora, and S.O. Purvine, et al. 2021. "Decrypting bacterial polyphenol metabolism in an anoxic wetland soil." Nature Communications 12, no. 1:2466. PNNL-SA-155819. doi:10.1038/s41467-021-22765-1
  • Smercina D.N., A. Bowsher, S. Evans, M.L. Friesen, E. Eder, D.W. Hoyt, and L.K. Tiemann. 2021. "Switchgrass Rhizosphere Metabolite Chemistry Driven by Nitrogen Availability." Phytobiomes Journal 5, no. 1:88-96. PNNL-SA-152631. doi:10.1094/PBIOMES-09-19-0055-FI
  • Wilson R.M., M.M. Tfaily, M. Kolton, E.R. Johnston, C. Petro, C.A. Zalman, and P.J. Hanson, et al. 2021. "Soil metabolome response to whole-ecosystem warming at the Spruce and Peatland Responses under Changing Environments experiment." Proceedings of the National Academy of Sciences (PNAS) 118, no. 25:e2004192118. PNNL-SA-152358. doi:10.1073/pnas.2004192118

2020

  • Bowers G.M., E.D. Walter, S.D. Burton, K.C. Schwarz, D.W. Hoyt, and R.J. Kirkpatrick. 2020. "Probing Pore Size and Connectivity in Porous Silicas Using 13C MAS NMR Spectroscopy of Supercritical Methane." Journal of Physical Chemistry C 124, no. 21:11536-11543. PNNL-SA-153506. doi:10.1021/acs.jpcc.0c02718
  • Ilhan Z.E., J.K. DiBaise, S.E. Dautel, N.G. Isern, Y. Kim, D.W. Hoyt, and A.A. Schepmoes, et al. 2020. "Temporospatial shifts in the human gut microbiome and metabolome after gastric bypass surgery." NPJ Biofilms and Microbiomes 6, no. 1:Article No. 12. PNNL-SA-133750. doi:10.1038/s41522-020-0122-5
  • Khare S., G.M. Deloid, R.M. Molina, K. Gokulan, S.P. Couvillion, K.J. Bloodsworth, and E.K. Eder, et al. 2020. "Effects of ingested nanocellulose on intestinal microbiota and homeostasis in Wistar Han rats." NanoImpact 18. PNNL-SA-149247. doi:10.1016/j.impact.2020.100216
  • Loring J.S., E.D. Walter, D.W. Hoyt, and C.J. Thompson. 2020. Multimodal Instrument Platform for High-Pressure MAS-NMR and IR Spectroscopic Interrogation. PNNL-30427. Richland, WA: Pacific Northwest National Laboratory. Multimodal Instrument Platform for High-Pressure MAS-NMR and IR Spectroscopic Interrogation

2019

  • Booker A.E., D.W. Hoyt, T. Meulia, E.K. Eder, C.D. Nicora, S.O. Purvine, and R. Daly, et al. 2019. "Deep-Subsurface Pressure Stimulates Metabolic Plasticity in Shale-Colonizing Halanaerobium spp." Applied and Environmental Microbiology 85, no. 12:e00018-19. PNNL-SA-144542. doi:10.1128/AEM.00018-19
  • Bowers G.M., H.T. Schaef, Q. Miller, E.D. Walter, S.D. Burton, D.W. Hoyt, and J.A. Horner, et al. 2019. "13C Nuclear Magnetic Resonance Spectroscopy of Methane and Carbon Dioxide in a Natural Shale." ACS Earth and Space Chemistry 3, no. 3:324-328. PNNL-SA-140683. doi:10.1021/acsearthspacechem.8b00214
  • Bowers G.M., J.S. Loring, E.D. Walter, S.D. Burton, M.E. Bowden, D.W. Hoyt, and B.W. Arey, et al. 2019. "Influence of Smectite Structure and Hydration on Supercritical Methane Binding and Dynamics in Smectite Pores." Journal of Physical Chemistry C 123, no. 48:29231-29244. PNNL-SA-146425. doi:10.1021/acs.jpcc.9b08875
  • Chamas A., L. Qi, H.S. Mehta, J.A. Sears, S.L. Scott, E.D. Walter, and D.W. Hoyt. 2019. "High Temperature/Pressure MAS-NMR for the Study of Dynamic Processes in Mixed Phase Systems." Magnetic Resonance Imaging 56. PNNL-SA-138048. doi:10.1016/j.mri.2018.09.026
  • Daly R., S. Roux, M. Borton, D.M. Morgan, M.D. Johnston, A.E. Booker, and D.W. Hoyt, et al. 2019. "Viruses control dominant bacteria colonizing the terrestrial deep biosphere after hydraulic fracturing." Nature Microbiology 4, no. 2:352-361. PNNL-SA-134613. doi:10.1038/s41564-018-0312-6
  • Evans M.V., G. Getzinger, J.L. Luek, A.J. Hanson, M.C. McLaughlin, J. Blotevogel, and S. Welch, et al. 2019. "In situ transformation of ethoxylate and glycol surfactants by shale-colonizing microorganisms during hydraulic fracturing." The ISME Journal 13, no. 11:2690-2700. PNNL-SA-141428. doi:10.1038/s41396-019-0466-0
  • Fudyma J.D., J.E. Lyon, R. Aminitabrizi, H. Gieschen, R.K. Chu, D.W. Hoyt, and J.E. Kyle, et al. 2019. "Untargeted metabolomic profiling of Sphagnum fallax reveals novel antimicrobial metabolites." Plant Direct 3, no. 11:Article No. e00179. PNNL-SA-146621. doi:10.1002/pld3.179
  • Lynch L.M., M. Machmuller, C.M. Boot, T.P. Covino, C.D. Rithner, F. Cotrufo, and D.W. Hoyt, et al. 2019. "Dissolved organic matter chemistry and transport along an Arctic Tundra Hillslope." Global Biogeochemical Cycles 33, no. 1:47-62. PNNL-SA-136691. doi:10.1029/2018GB006030
  • Mehta H.S., Y. Chen, J.A. Sears, E.D. Walter, M. Campos, J. Kothandaraman, and D.J. Heldebrant, et al. 2019. "A Novel High-Temperature MAS Probe with Optimized Temperature Gradient across Sample Rotor for In-situ Monitoring of High-Temperature High-Pressure Chemical Reactions." Solid State Nuclear Magnetic Resonance 102. PNNL-SA-143153. doi:10.1016/j.ssnmr.2019.06.003
  • Miller Q., D.A. Dixon, S.D. Burton, E.D. Walter, D.W. Hoyt, A.S. Mcneill, and J. Moon, et al. 2019. "Surface-Catalyzed Oxygen Exchange during Mineral Carbonation in Nanoscale Water Films." Journal of Physical Chemistry C 123, no. 20:12871-12885. PNNL-SA-141756. doi:10.1021/acs.jpcc.9b02215
  • Narrowe A.B., M. Borton, D.W. Hoyt, G. Smith, R. Daly, J. Angle, and E. Eder, et al. 2019. "Uncovering the Diversity and Activity of Methylotrophic Methanogens in Freshwater Wetland Soils." mSystems 4, no. 6:e00320-19. PNNL-SA-152910. doi:10.1128/mSystems.00320-19
  • Qi L., A. Chamas, Z.R. Jones, E.D. Walter, D.W. Hoyt, N.M. Washton, and S.L. Scott. 2019. "Unraveling the Dynamic Network in the Reactions of an Alkyl Aryl Ether Catalyzed by Ni/y-Al2O3 in 2-Propanol." Journal of the American Chemical Society 141, no. 43:17370-17381. PNNL-SA-148402. doi:10.1021/jacs.9b09071
  • Sharon G., N.J. Cruz, D. Kang, M. Gandal, B. Wang, Y. Kim, and E.M. Zink, et al. 2019. "Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice." Cell 177, no. 6:1600-1618. PNNL-SA-131563. doi:10.1016/j.cell.2019.05.004
  • Stavila V., M. Foster, J.W. Brown, R.W. Davis, J. Edgington, A.I. Benin, and R.A. Zarkesh, et al. 2019. "IRMOF-74(n)-Mg: a novel catalyst series for hydrogen activation and hydrogenolysis of C-O bonds." Chemical Science 10, no. 42:9880-9892. PNNL-SA-147308. doi:10.1039/C9SC01018A
  • Tfaily M., R.M. Wilson, H.M. Brewer, R.K. Chu, H.M. Heyman, D.W. Hoyt, and J.E. Kyle, et al. 2019. "Single-throughput complementary high-resolution analytical techniques for characterizing complex natural organic matter mixtures." Journal of Visualized Experiments. PNNL-SA-138197. doi:10.3791/59035
  • Wang G., Z. Zhao, J. Ke, Y. Engel, Y. Shi, D.S. Robinson, and A.K. Bingol, et al. 2019. "CRAGE enables rapid activation of biosynthetic gene clusters in undomesticated bacteria." Nature Microbiology 4, no. 12:2498-2510. PNNL-SA-133313. doi:10.1038/s41564-019-0573-8

2018

  • Borton M., D.W. Hoyt, S. Roux, R. Daly, S. Welch, C.D. Nicora, and S.O. Purvine, et al. 2018. "Coupled laboratory and field investigations resolve microbial interactions that underpin persistence in hydraulically fractured shales." Proceedings of the National Academy of Sciences (PNAS) 115, no. 28:E6585-E6594. PNNL-SA-134972. doi:10.1073/pnas.1800155115
  • Borton M., R. Daly, B. O'Banion, D.W. Hoyt, D.N. Marcus, S. Welch, and S.S. Hastings, et al. 2018. "Comparative genomics and physiology of the genus Methanohalophilus, a prevalent methanogen in hydraulically fractured shale." Environmental Microbiology 20, no. 12:4596-4611. PNNL-SA-138432. doi:10.1111/1462-2920.14467
  • Bowers G.M., J.S. Loring, H.T. Schaef, E.D. Walter, S.D. Burton, D.W. Hoyt, and S.S. Cunniff, et al. 2018. "Interaction of Hydrocarbons with Clays under Reservoir Conditions: In Situ Infrared and Nuclear Magnetic Resonance Spectroscopy and X-ray Diffraction for Expandable Clays with Variably Wet Supercritical Methane." ACS Earth and Space Chemistry 2, no. 7:640-652. PNNL-SA-136218. doi:10.1021/acsearthspacechem.8b00039
  • Kang D., Z.E. Ilhan, N.G. Isern, D.W. Hoyt, D.P. Howsmon, M. Shaffer, and C. Lozupone, et al. 2018. "Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders." Anaerobe 49. PNNL-SA-127135. doi:10.1016/j.anaerobe.2017.12.007
  • Kothandaraman J., R.A. Dagle, V. Dagle, S.D. Davidson, E.D. Walter, S.D. Burton, and D.W. Hoyt, et al. 2018. "Condensed-Phase Low Temperature Heterogeneous Hydrogenation of CO2 to Methanol." Catalysis Science & Technology 8, no. 19:5098-5103. PNNL-SA-133245. doi:10.1039/C8CY00997J
  • Roy Chowdhury T., L.M. Bramer, D.W. Hoyt, Y. Kim, T.O. Metz, L. McCue, and H.L. Diefenderfer, et al. 2018. "Temporal dynamics of CO2 and CH4 loss potentials in response to rapid hydrological shifts in tidal freshwater wetland soils." Ecological Engineering 114. PNNL-SA-123359. doi:10.1016/j.ecoleng.2017.06.041
  • Solden L., A. Naas, S. Roux, R. Daly, W.B. Collins, C.D. Nicora, and S.O. Purvine, et al. 2018. "Interspecies cross-feeding orchestrates carbon degradation in the rumen ecosystem." Nature Microbiology 3, no. 11:1274-1284. PNNL-SA-131180. doi:10.1038/s41564-018-0225-4
  • Walter E.D., L. Qi, A. Chamas, H.S. Mehta, J.A. Sears, S.L. Scott, and D.W. Hoyt. 2018. "Operando MAS NMR Reaction Studies at High Temperatures and Pressures." Journal of Physical Chemistry C 122, no. 15:8209-8215. PNNL-SA-130852. doi:10.1021/acs.jpcc.7b11442

2017

  • Angle J., T.A. Morin, L. Solden, A.B. Narrowe, G.J. Smith, M. Borton, and C. Rey-Sanchez, et al. 2017. "Methanogenesis in oxygenated soils is a substantial fraction of wetland methane emissions." Nature Communications 8. PNNL-SA-125731. doi:10.1038/s41467-017-01753-4
  • Booker A.E., M. Borton, R. Daly, S. Welch, C.D. Nicora, D.W. Hoyt, and T. Wilson, et al. 2017. "Sulfide Generation by Dominant Halanaerobium Microorganisms in Hydraulically Fractured Shales." mSphere 2. PNNL-SA-128950. doi:10.1128/mSphereDirect.00257-17
  • Bowers G.M., H.T. Schaef, J.S. Loring, D.W. Hoyt, S.D. Burton, E.D. Walter, and R.J. Kirkpatrick. 2017. "Role of Cations in CO2 Adsorption, Dynamics, and Hydration in Smectite Clays Under in situ Supercritical CO2 Conditions." Journal of Physical Chemistry C 121, no. 1:577-592. PNNL-SA-122523. doi:10.1021/acs.jpcc.6b11542
  • Dalcin Martins P., D.W. Hoyt, S. Bansal, C. Mills, M.M. Tfaily, B.A. Tangen, and R.G. Fincchiaro, et al. 2017. "Abundant carbon substrates drive extremely high sulfate reduction rates and methane fluxes in Prairie Pothole Wetlands." Global Change Biology 23, no. 8:3107-3120. PNNL-SA-120033. doi:10.1111/gcb.13633
  • Ilhan Z.E., J.K. DiBaise, N.G. Isern, D.W. Hoyt, A.K. Marcus, D. Kang, and M. Crowell, et al. 2017. "Distinctive microbiomes and metabolites linked with weight loss after gastric bypass, but not gastric banding." The ISME Journal 11, no. 9:2047-2058. PNNL-SA-119449. doi:10.1038/ismej.2017.71
  • Ok S., D.W. Hoyt, A. Andersen, J. Sheets, S. Welch, D.R. Cole, and K.T. Mueller, et al. 2017. "Surface Interactions and Confinement of Methane: A High Pressure Magic Angle Spinning NMR and Computational Chemistry Study." Langmuir 33, no. 6:1359-1367. PNNL-SA-123185. doi:10.1021/acs.langmuir.6b03590
  • Qi L., R. Alamillo, W.A. Elliott, A. Andersen, D.W. Hoyt, E.D. Walter, and K. Han, et al. 2017. "Operando solid-state NMR observations of solvent-mediated adsorption-reaction of carbohydrates in zeolites." ACS Catalysis 7, no. 5:3489-3500. PNNL-SA-119548. doi:10.1021/acscatal.7b01045
  • Schaef H.T., N. Loganathan, G.M. Bowers, R.J. Kirkpatrick, A.O. Yazaydin, S.D. Burton, and D.W. Hoyt, et al. 2017. "Tipping Point for Expansion of Layered Aluminosilicates in Weakly Polar Solvents: Supercritical CO2." ACS Applied Materials & Interfaces 9, no. 42:36783-36791. PNNL-SA-127664. doi:10.1021/acsami.7b10590
  • Solden L., D.W. Hoyt, W.B. Collins, J.E. Plank, R. Daly, E. Hildebrand, and T.J. Beavers, et al. 2017. "New roles in hemicellulosic sugar fermentation for the uncultivated Bacteroidetes family BS11." The ISME Journal 11, no. 3:691-703. PNNL-SA-115562. doi:10.1038/ismej.2016.150

2016

  • Daly R., M.A. Borton, M.J. Wilkins, D.W. Hoyt, D.J. Kountz, R. Wolfe, and S. Welch, et al. 2016. "Microbial metabolisms in a new 2.5 km deep ecosystem created by hydraulic fracturing in shales." Nature Microbiology 1, no. 10:Article No. 16146. PNNL-SA-115522. doi:10.1038/nmicrobiol.2016.146
  • Walker L.R., D.W. Hoyt, S. Walker, J.K. Ward, C.D. Nicora, and A.K. Bingol. 2016. "Unambiguous Metabolite Identification in High-throughput Metabolomics by Hybrid 1D 1H NMR/ESI MS1 Approach." Magnetic Resonance in Chemistry 54, no. 12:998-1003. PNNL-SA-117020. doi:10.1002/mrc.4503

2015

  • Jung H., K. Carroll, S. Kabilan, D.J. Heldebrant, D.W. Hoyt, L. Zhong, and T. Varga, et al. 2015. "Stimuli-Responsive/Rheoreversible Hydraulic Fracturing Fluids as a Greener Alternative to Support Geothermal and Fossil Energy Production." Green Chemistry 17, no. 5:2799-2812. PNNL-SA-106027. doi:10.1039/c4gc01917b

2014

  • Bowers G.M., D.W. Hoyt, S.D. Burton, B.O. Ferguson, T. Varga, and R.J. Kirkpatrick. 2014. "In Situ 13C and 23Na Magic Angle Spinning NMR Investigation of Supercritical CO2 Incorporation in Smectite-Natural Organic Matter Composites." Journal of Physical Chemistry C 118, no. 7:3564-3573. PNNL-SA-99489. doi:10.1021/jp410535d
  • Wilkins M.J., D.W. Hoyt, M.J. Marshall, P.A. Alderson, A.E. Plymale, L.M. Markillie, and A.E. Tucker, et al. 2014. "CO2 exposure at pressure impacts metabolism and stress responses in the model sulfate-reducing bacterium Desulfovibrio vulgaris strain Hildenborough." Frontiers in Microbiology 5. PNNL-SA-103791. doi:10.3389/fmicb.2014.00507

2013

  • Feng J., J.Z. Hu, S.D. Burton, and D.W. Hoyt. 2013. "High Resolution Magic Angle Spinning 1H-NMR Metabolic Profiling of Nanoliter Biological Tissues at High Magnetic Field." Chinese Journal of Magnetic Resonance 30, no. 1:1-11. PNNL-SA-89007.
  • Loring J.S., H.T. Schaef, C.J. Thompson, R.V. Turcu, Q.R. Miller, J. Chen, and J.Z. Hu, et al. 2013. "Clay hydration/dehydration in dry to water-saturated supercritical CO2: Implications for caprock integrity." Energy Procedia 37. PNNL-SA-91508. doi:10.1016/j.egypro.2013.06.463
  • Miller Q., C.J. Thompson, J.S. Loring, C.F. Windisch, M.E. Bowden, D.W. Hoyt, and J.Z. Hu, et al. 2013. "Insights into Silicate Carbonation Processes in Water-Bearing Supercritical CO2 Fluids." International Journal of Greenhouse Gas Control 15. PNNL-SA-89916. doi:10.1016/j.ijggc.2013.02.005
  • Turcu R.V., D.W. Hoyt, K.M. Rosso, J.A. Sears, J.S. Loring, A.R. Felmy, and J.Z. Hu. 2013. "Rotor Design for High Pressure Magic Angle Spinning Nuclear Magnetic Resonance." Journal of Magnetic Resonance 226. PNNL-SA-88703. doi:10.1016/j.jmr.2012.08.009

2012

  • Hu J.Z., J.A. Sears, H.S. Mehta, J.J. Ford, J. Kwak, K. Zhu, and Y. Wang, et al. 2012. "A Large Sample Volume Magic Angle Spinning Nuclear Magnetic Resonance Probe for In-Situ Investigations with Constant Flow of Reactants." Physical Chemistry Chemical Physics 14, no. 7:2137-2143. PNNL-SA-82533. doi:10.1039/c1cp22692d
  • Loring J.S., H.T. Schaef, R.V. Turcu, C.J. Thompson, Q. Miller, P.F. Martin, and J.Z. Hu, et al. 2012. "In Situ Molecular Spectroscopic Evidence for CO2 Intercalation into Montmorillonite in Supercritical Carbon Dioxide." Langmuir 28, no. 18:7125-7128. PNNL-SA-86500. doi:10.1021/la301136w

2011

  • Hoyt D.W., R.V. Turcu, J.A. Sears, K.M. Rosso, S.D. Burton, A.R. Felmy, and J.Z. Hu. 2011. "High-pressure Magic Angle Spinning Nuclear Magnetic Resonance." Journal of Magnetic Resonance 212, no. 2:378-385. PNNL-SA-80681. doi:10.1016/j.jmr.2011.07.019
  • Hoyt D.W., R.V. Turcu, J.A. Sears, K.M. Rosso, S.D. Burton, J. Kwak, and A.R. Felmy, et al. 2011. "IN SITU MAGIC ANGLE SPINNING NMR FOR STUDYING GEOLOGICAL CO(2) SEQUESTRATION." In 241st National Meeting and Exposition of the American Chemical Society, March 27-31, 2011, Anaheim, California, 241, 245-Fuel. Washington Dc:American Chemical Society. PNNL-SA-77039.
  • Kwak J., J.Z. Hu, R.V. Turcu, K.M. Rosso, E.S. Ilton, C.M. Wang, and J.A. Sears, et al. 2011. "The Role of H2O in the Carbonation of Forsterite in Supercritical CO2." International Journal of Greenhouse Gas Control 5, no. 4:1081-1092. PNNL-SA-76665. doi:10.1016/j.ijggc.2011.05.013
  • Teklemichael S.T., W. Oo, M. Matthew, E.D. Walter, and D.W. Hoyt. 2011. "Acceptors in ZnO nanocrystals." Applied Physics Letters 98, no. 23:Article No. 232112. PNNL-SA-79839. doi:10.1063/1.3598411
  • White M.D., B.P. McGrail, H.T. Schaef, J.Z. Hu, D.W. Hoyt, A.R. Felmy, and K.M. Rosso, et al. 2011. "Multiphase Sequestration Geochemistry: Model for Mineral Carbonation." Energy Procedia 4. PNNL-SA-74658. doi:10.1016/j.egypro.2011.02.472

2010

  • Kwak J., J.Z. Hu, D.W. Hoyt, J.A. Sears, C.M. Wang, K.M. Rosso, and A.R. Felmy. 2010. "Metal Carbonation of Forsterite in Supercritical CO2 and H2O Using Solid State 29Si, 13C NMR Spectroscop." Journal of Physical Chemistry C 114, no. 9:4126 - 4134. PNNL-SA-68897. doi:10.1021/jp1001308

2009

  • Chen B., X. Ren, T. Neville, W. Jerome, D.W. Hoyt, D.L. Sparks, and G. Ren, et al. 2009. "Apolipoprotein AI tertiary structures determine stability and phospholipid-binding activity of discoidal high-density lipoprotein particles of different sizes." Protein Science 18, no. 5:921-935. PNNL-SA-56783. doi:10.1002/pro.101
  • Hu J.Z., J.A. Sears, J. Kwak, D.W. Hoyt, Y. Wang, and C.H. Peden. 2009. "An Isotropic Chemical Shift-Chemical Shift Anisotropic Correlation Experiment Using Discrete Magic Angle Turning." Journal of Magnetic Resonance 198, no. 1:105-110. PNNL-SA-63634.

2008

  • Briknarova K., X. Zhou, A.C. Satterthwait, D.W. Hoyt, K.R. Ely, S. Huang, and S. Huang. 2008. "Structural Studies of the SET Domain from RIZ1 Tumor Suppressor." Biochemical and Biophysical Research Communications 366, no. 3:807-813. PNNL-SA-56117. doi:10.1016/j.bbrc.2007.12.034

2007

  • Ren X., Y. Yang, T. Neville, T. Neville, D.W. Hoyt, D.L. Sparks, and J. Wang. 2007. "A complete backbone spectral assignment of human apolipoprotein AI on a 38 kDa preßHDL (Lp1-AI) particle." Biomolecular NMR Assignments 1, no. 1:69-71. PNNL-SA-53926.
  • Smirnov S., N.G. Isern, Z.G. Jiang, D.W. Hoyt, and C.J. Mcknight. 2007. "The Isolated Sixth Gelsolin Repeat and Headpiece Domain of Villin Bundle F-Actin in the Presence of Calcium and Are Linked by a 40-Residue Unstructured Sequence." Biochemistry 46, no. 25:7488-7496. PNNL-SA-55624. doi:10.1021/bi700110v
  • Yang Y., D.W. Hoyt, and J. Wang. 2007. "A Complete NMR Spectral Assignment of the Lipid-free Mouse Apolipoprotein A-I (ApoAI) C-terminal Truncation Mutant, ApoAI(1-216)." Biomolecular NMR Assignments 1, no. 1:109-111. PNNL-SA-53927. doi:10.1007/s12104-007-9031-2

2006

  • Brzovic P.S., A.V. Lissounov, D. Christensen, D.W. Hoyt, and R.E. Klevit. 2006. "A UbcH5/Ubiquitin Noncovalent Complex is Required for Processive BRCA1-Directed Ubiquitination." Molecular Cell 21, no. 6:873-880. PNNL-SA-48810.

2005

  • Briknarova K., F. Nasertorabi, M.L. Havert, E. Eggleston, D.W. Hoyt, C. Li, and A.J. Olson, et al. 2005. "The Serine-rich Domain from Crk-associated Substrate (p130Cas) is a Four-helix Bundle." Journal of Biological Chemistry 280, no. 23:21908-21914. PNNL-SA-45324.
  • Xu C., A. Sivashanmugam, D.W. Hoyt, and J. Wang. 2005. "A Complete Backbone Assignment of the Apolipoprotein E LDL Receptor Binding Domain [Letter to the Editor]." Journal of Biomolecular NMR 32, no. 2:177. PNNL-SA-44749. doi:10.1007/s10858-005-6729-2

2004

  • Hoyt D.W., S.D. Burton, M.R. Peterson, J.D. Myers, and G. Chin. 2004. "Expanding Your Laboratory by Accessing Collaboratory Resources." Analytical and Bioanalytical Chemistry 378, no. 6:1408-1410. PNNL-SA-39416.

2003

  • Briknarova K., M. Akermann, D.W. Hoyt, E. Ruoslahti, and K.R. Ely. 2003. "Anastellin, an FN3 Fragment with Fibronectin Polymerization Activity, Resembles Amyloid Fibril Precursors." Journal of Molecular Biology 332, no. 1:205-215. PNNL-SA-38930.
  • Kreishman-Detrick M., C. Egile, D.W. Hoyt, J.J. Ford, R. Li, and M.K. Rosen. 2003. "NMR analysis of methyl groups at 100-500 kDa: model systems and Arp2/3 complex." Biochemistry 42, no. 28:8579-8586. PNNL-SA-39415.
  • Lowry D.F., D.W. Hoyt, F.A. Khazi, J.R. Bagu, A.G. Lindsey, and D.M. Wilson Iii. 2003. "Investigation of the role of the histidine-aspartate pair in the human exonuclease III-like abasic endonuclease, Ape1." Journal of Molecular Biology 329, no. 2:311-322. PNNL-SA-40864.
  • Lowry D.F., D.W. Hoyt, F.A. Khazi, J.R. Bagu, A.G. Lindsey, and D.M. Wilson. 2003. "Investigation of the Role of the Histidine-Aspartate Pair in the Human Exonuclease III-like Abasic Endonuclease, Ape1." Journal of Molecular Biology 329, no. 2:311-322. PNNL-SA-36499.

2002

  • Briknarova K., S. Takayama, S. Homma, K. Baker, E. Cabezas, D.W. Hoyt, and Z. Li, et al. 2002. "BAG4/SODD Protein Contains a Short BAG Domain." Journal of Biological Chemistry 277, no. 34:31172-31178. PNNL-SA-36503.
  • Chin G., J.D. Myers, and D.W. Hoyt. 2002. "Social Networks in the Virtual Science Laboratory." Communications of the ACM 45, no. 8:87-92. PNNL-SA-35242.

2001

  • Briknarova K., S. Takayama, L. Brive, M.L. Havert, D.A. Knee, J. Velasco, and S. Homma, et al. 2001. "Structural Analysis of BAG1 Cochaperone and Its Interactions With Hsc70 Heat Shock Protein." Nature Structural Biology 8, no. 4:349-352. PNNL-SA-33922.
  • Bryant P.L., C. Harwell, A.A. Mrse, E.F. Emery, Z. Gan, T. Caldwell, and A.P. Reyes, et al. 2001. "Structural Characterization of MAO and Related Aluminum Complexes. 1. Solid-State 27 Al NMR with Comparison to EFG Tensors from ab Initio Molecular Orbital Calculations." Journal of the American Chemical Society 123. PNNL-SA-33924.
  • Brzovic P.S., P. Rajagopal, D.W. Hoyt, M. King, and R.E. Klevit. 2001. "Structure of a BRCA1/BARD1 Complex: a Heterodimeric RING-RING Interaction." Nature Structural Biology 8, no. 10:833-837. PNNL-SA-34960.

2000

  • Liu K., H.S. Cho, D.W. Hoyt, T.N. Nguyen, P. Olds, J.W. Kelly, and D. Wemmer. 2000. "Deuterium-proton Exchange on the Native Wild-type Transthyretin Tetramer Identifies the Stable Core of the Individual Subunits and Indicates Mobility at the Subunit Interface." Journal of Molecular Biology 303, no. 4:555-565. PNNL-SA-33925.

1998

  • Buchko G.W., A. Rozek, D.W. Hoyt, R.J. Cushley, and M.A. Kennedy. 1998. "The Use of Sodium Dodecyl Sulfate To Model the Apolipoprotein Environment. Evidence for Peptide-SDS Complexes Using Pulsed-Field-Gradient NMR Spectroscopy." Biochimica et Biophysica Acta--Lipids and Lipid Metabolism 1392, no. 1:101-108. PNNL-SA-28911. doi:10.1016/S0005-2760(98)00028-9