PNNL

Dr. David Hoyt is a chemist in PNNL’s Environmental and Molecular Sciences Division, supporting the Environmental Molecular Sciences Laboratory (EMSL) user program. Hoyt has over 30 years of experience with research related to nuclear magnetic resonance (NMR) and other forms of spectroscopy. His research focus has been on the structure and dynamics of bio-complexes and metabolite identification via NMR. More recently, his interests have broadened to include biogeochemistry and NMR specialty-probe development projects. Hoyt has co-authored peer-reviewed publications in Nature Microbiology, Nature Communications, Nature Structural Biology, PNAS, Cell, ISME, Molecular Cell, JACS, Biochemistry, and Journal of Magnetic Resonance.  

For 10 years, Hoyt served in EMSL management and for over 25 years in technical support of the EMSL user program—providing research collaboration in high-field liquids NMR with structural biology and metabolomics applications, as well as in situ chemistry projects.  

Hoyt was responsible to site and develop ~$12 million in new American Reinvestment and Recovery Act funded magnetic resonance systems between June 2009 and November 2011. He has also served as project manager of several recent procurements for PNNL. From 2002 to present he worked to site and develop over $40 million in NMR and electron paramagnetic resonance equipment with EMSL operations. This work included enhancements to in situ controlled-environment NMR and metabolomics capabilities. His leadership on the R&D team for high-temperature and high-pressure NMR rotor capability development for in situ measurements of mixed-phased chemistry and biologics has recently led to licensing by Revolution NMR LLC (Fort Collins, CO). His present interests now include advancing PNNL and EMSL science through further work developing and participating in research and R&D of integrated capabilities related to biological, environmental, and molecular-interface contexts.

• NMR 

• Metabolomics 

• NMR technology development for controlled sample environments to aid in situ measurements 

• Supercritical fluid/mineral/microbe nteractions 

• Bio-oils and biofuels 

• Structural basis for protein-protein interactions 

• Other spectroscopies: CD, fluorescence 

• PhD in Biochemistry, University of Texas Southwestern Medical Center, 1990 

• MA in Biochemistry, University of Delaware, 1987 

• BS in Chemistry, Millersville University, 1983 

• Past Reviewer, Small Business Innovation Research and Small Business Technology Transfer Program, Office of Science, U.S. Department of Energy  

• Past Reviewer, Chemical Research Instrumentation and Facility, National Science Foundation  

• Past Reviewer, Natural Sciences and Engineering Research Council of Canada  

• Past Reviewer, Computing in Science & Engineering  

• American Chemical Society 

• American Association for the Advancement of Science 

• American Geophysical Union 

• American Society for Microbiology 

• Metabolomics Society 

• Best Paper Award, Earth and Biological Sciences Directorate (2019, 2017) 

• Top 100 Stories of 2016 for "Digging Deep for New Bacteria," related to 2016 publication in Nature Microbiology. Discover Magazine (2016) 

• R&D100 Award for “Pressurized Magic Angle Spinning, Technology for Nuclear Magnetic Resonance Spectroscopy." (2015) 

• Individual and Team Outstanding Performance Awards, PNNL (1999 – 2011)  

• Director Award for Outstanding Contributions, EMSL (2004) 

• Director Award for Laboratory Equipment Distinguished Manager, EMSL (2004) 

• ED Walter, JA Sears, HS Mehta, DW Hoyt. 2020. “Snap-in Bushings and Process for High-Pressure and/or High Temperature Magic Angle Spinning Nuclear Magnetic Resonance” US Patent No. 10,550,889. 

• JZ Hu, JA Sears, DW Hoyt, HS Mehta, CHF Peden. 2015. “Magic Angle Spinning Nuclear Magnetic Resonance Apparatus and Process for High-Resolution In Situ Investigations.” U.S. Patent No. 9,194,920. 

• DW Hoyt, JA. Sears, RVF Turcu, KM Rosso, and JZ Hu. 2014. “Devices and Process for High-Pressure Magic Angle Spinning Nuclear Magnetic Resonance.” U.S. Patent No. 8,692,548.  

• JZ Hu, JA Sears, DW Hoyt, and RA Wind. 2009. “Discrete Magic Angle Turning System, Apparatus and Process for In Situ Magnetic Resonance Spectroscopy and Imaging.” U.S. Patent No. 7,535,224.   

• ED Walter, JA Sears, HS Mehta, DW Hoyt. Filed June 1, 2017. “Snap-in Bushings and Process for High-Pressure and/or High Temperature Magic Angle Spinning Nuclear Magnetic Resonance.” German Patent Pending – DE201710112768  (IPID-30618-E-DE).  

• ED Walter, JA Sears, HS Mehta, DW Hoyt. Filed July 1, 2017. “Snap-in Bushings and Process for High-Pressure and/or High Temperature Magic Angle Spinning Nuclear Magnetic Resonance” Japan Patent Pending - JP2017144364A (IPID-30618-E-JP). 

2020 

Bowers G.M., E.D. Walter, S.D. Burton, K.C. Schwarz, D.W. Hoyt, and R.J. Kirkpatrick. 2020. "Probing Pore Size and Connectivity in Porous Silicas Using 13C MAS NMR Spectroscopy of Supercritical Methane." Journal of Physical Chemistry C 124, no. 21:11536-11543. PNNL-SA-153506. doi:10.1021/acs.jpcc.0c02718 

Ilhan Z.E., J.K. DiBaise, S.E. Dautel, N.G. Isern, Y. Kim, D.W. Hoyt, and A.A. Schepmoes, et al. 2020. "Temporospatial shifts in the human gut microbiome and metabolome after gastric bypass surgery." NPJ Biofilms and Microbiomes 6, no. 1:Article No. 12. PNNL-SA-133750. doi:10.1038/s41522-020-0122-5 

Khare S., G.M. Deloid, R.M. Molina, K. Gokulan, S.P. Couvillion, K.J. Bloodsworth, and E.K. Eder, et al. 2020. "Effects of ingested nanocellulose on intestinal microbiota and homeostasis in Wistar Han rats." NanoImpact 18. PNNL-SA-149247. doi:10.1016/j.impact.2020.100216 

Smercina, D.N.; Bowsher, A.W.; Evans, S.E.; Friesen, M.L.; Eder, E.K.; Hoyt, D.W.; Tiemann, L.K. 2020. “Switchgrass Rhizosphere Metabolite Chemistry Driven by Nitrogen Availability.” Phytobiomes Journal. PNNL-SA-152631  DOI: 10.1094/PBIOMES-09-19-0055-FI   

2019 

Booker A.E., D.W. Hoyt, T. Meulia, E.K. Eder, C.D. Nicora, S.O. Purvine, and R. Daly, et al. 2019. "Deep-Subsurface Pressure Stimulates Metabolic Plasticity in Shale-Colonizing Halanaerobium spp." Applied and Environmental Microbiology 85, no. 12:e00018-19. PNNL-SA-144542. doi:10.1128/AEM.00018-19 

Bowers G.M., H.T. Schaef, Q. Miller, E.D. Walter, S.D. Burton, D.W. Hoyt, and J.A. Horner, et al. 2019. "13C Nuclear Magnetic Resonance Spectroscopy of Methane and Carbon Dioxide in a Natural Shale." ACS Earth and Space Chemistry 3, no. 3:324-328. PNNL-SA-140683. doi:10.1021/acsearthspacechem.8b00214 

Bowers G.M., J.S. Loring, E.D. Walter, S.D. Burton, M.E. Bowden, D.W. Hoyt, and B.W. Arey, et al. 2019. "Influence of Smectite Structure and Hydration on Supercritical Methane Binding and Dynamics in Smectite Pores." Journal of Physical Chemistry C 123, no. 48:29231-29244. PNNL-SA-146425. doi:10.1021/acs.jpcc.9b08875 

Chamas A., L. Qi, H.S. Mehta, J.A. Sears, S.L. Scott, E.D. Walter, and D.W. Hoyt. 2019. "High Temperature/Pressure MAS-NMR for the Study of Dynamic Processes in Mixed Phase Systems." Magnetic Resonance Imaging 56. PNNL-SA-138048. doi:10.1016/j.mri.2018.09.026 

Daly R., S. Roux, M. Borton, D.M. Morgan, M.D. Johnston, A.E. Booker, and D.W. Hoyt, et al. 2019. "Viruses control dominant bacteria colonizing the terrestrial deep biosphere after hydraulic fracturing." Nature Microbiology 4, no. 2:352-361. PNNL-SA-134613. doi:10.1038/s41564-018-0312-6 

Evans M.V., G. Getzinger, J.L. Luek, A.J. Hanson, M.C. McLaughlin, J. Blotevogel, and S. Welch, Nicora, C.D.; Purvine, S.O.; Xu, C.; Cole, D.R.; Darrah, T.H.; Hoyt, D.W.; Metz, T.O.; Ferguson, P.L.; Lipton, M.S.; Wilkins, M.J.; Mouser, P.J. 2019. "In situ transformation of ethoxylate and glycol surfactants by shale-colonizing microorganisms during hydraulic fracturing." The ISME Journal 13, no. 11:2690-2700. PNNL-SA-141428. doi:10.1038/s41396-019-0466-0 

Fudyma J.D., J.E. Lyon, R. Aminitabrizi, H. Gieschen, R.K. Chu, D.W. Hoyt, and J.E. Kyle, et al. 2019. "Untargeted metabolomic profiling of Sphagnum fallax reveals novel antimicrobial metabolites." Plant Direct 3, no. 11:Article No. e00179. PNNL-SA-146621. doi:10.1002/pld3.179 

Lynch L.M., M. Machmuller, C.M. Boot, T.P. Covino, C.D. Rithner, F. Cotrufo, and D.W. Hoyt, et al. 2019. "Dissolved organic matter chemistry and transport along an Arctic Tundra Hillslope." Global Biogeochemical Cycles 33, no. 1:47-62. PNNL-SA-136691. doi:10.1029/2018GB006030 

Mehta H.S., Y. Chen, J.A. Sears, E.D. Walter, M. Campos, J. Kothandaraman, and D.J. Heldebrant, et al. 2019. "A Novel High-Temperature MAS Probe with Optimized Temperature Gradient across Sample Rotor for In-situ Monitoring of High-Temperature High-Pressure Chemical Reactions." Solid State Nuclear Magnetic Resonance 102. PNNL-SA-143153. doi:10.1016/j.ssnmr.2019.06.003 

Miller Q., D.A. Dixon, S.D. Burton, E.D. Walter, D.W. Hoyt, A.S. Mcneill, and J. Moon, et al. 2019. "Surface-Catalyzed Oxygen Exchange during Mineral Carbonation in Nanoscale Water Films." Journal of Physical Chemistry C 123, no. 20:12871-12885. PNNL-SA-141756. doi:10.1021/acs.jpcc.9b02215 

Narrowe, A.B.; Borton, M.A.; Hoyt, D.W.; Smith, G.J.; Daly, R.A.; Angle, J.A.; Eder, E.K.; Wong, Q.R.; Wolfe, R.A.; Pappas, A.; Bohrer, G.; Miller, C.S.; Wrighton, K.C. 2019. “Uncovering the diversity and activity of methylotrophic methanogens in freshwater wetland soils.” mSystems 4(6) e00320-19. PNNL-SA-152910 DOI: 10.1128/mSystems.00320-19  

Qi L., A. Chamas, Z.R. Jones, E.D. Walter, D.W. Hoyt, N.M. Washton, and S.L. Scott. 2019. "Unraveling the Dynamic Network in the Reactions of an Alkyl Aryl Ether Catalyzed by Ni/y-Al2O3 in 2-Propanol." Journal of the American Chemical Society 141, no. 43:17370-17381. PNNL-SA-148402. doi:10.1021/jacs.9b09071 

Sharon G., N.J. Cruz, D. Kang, M. Gandal, B. Wang, Y. Kim, and E.M. Zink, et al. 2019. "Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice." Cell 177, no. 6:1600-1618. PNNL-SA-131563. doi:10.1016/j.cell.2019.05.004 

Stavila V., M. Foster, J.W. Brown, R.W. Davis, J. Edgington, A.I. Benin, and R.A. Zarkesh, et al. 2019. "IRMOF-74(n)-Mg: a novel catalyst series for hydrogen activation and hydrogenolysis of C-O bonds." Chemical Science 10, no. 42:9880-9892. PNNL-SA-147308. doi:10.1039/C9SC01018A 

Tfaily M., R.M. Wilson, H.M. Brewer, R.K. Chu, H.M. Heyman, D.W. Hoyt, and J.E. Kyle, et al. 2019. "Single-throughput complementary high-resolution analytical techniques for characterizing complex natural organic matter mixtures." Journal of Visualized Experiments. PNNL-SA-138197. doi:10.3791/59035 

Wang, G; Zhao, Z.; Ke, J.; Engel, Y.; Shi, YM.; Zhang, Z., Bingol, K; Robinson, D. Evans, R.; Miyamoto, Y.; Cheng, K.; Bowen, B.; Louie, K.; Kosina, S.; de Radd, M.; Silva, L.; Luhrs, A.; Lubbe, A.; Hoyt, D W..; Francavilla, C.; Ohtani, H.; Deutsch, S.; Washton, N. M.; Rubin, E.M.; Mouncey, N.; Visel, A.; Cheng, J.F.; Northen, T.; Bode, H.; Yoshikuni, Y. 2019. “Chassis-Independent Recombinase-Assisted Genome Engineering Enables Rapid Activation of  Biosynthetic Gene Clusters.” Nature Microbiology 2019 4, 2498-2510. PNNL-SA- 133313  DOI: 10.1038/s41564-019-0573-8   

2018 

Borton M., D.W. Hoyt, S. Roux, R. Daly, S. Welch, C.D. Nicora, and S.O. Purvine, et al. 2018. "Coupled laboratory and field investigations resolve microbial interactions that underpin persistence in hydraulically fractured shales." Proceedings of the National Academy of Sciences of the United States of America 115, no. 28:E6585-E6594. PNNL-SA-134972. doi:10.1073/pnas.1800155115 

Borton, M.A.; Daly, R.A.; O’Banion, B.O.; Hoyt, D.W.; Marcus, D.N.; Welch, S.; Hastings, S.; Meulia, T.; Wolfe, R.A.; Booker, A.E.; Sharma, S.; Cole, D.R.; Wunch, K.; Moore, J.D.; Thomas, D.; Wilkins, M.J.; Wrighton, K.C. 2018. “Comparative genomics and physiology of the genus Methanohalophilus, a prevalent methanogen in hydraulically fractured shale” Environmental Microbiology 20(12), 4596-4611. PNNL-SA-138432  DOI: 10.1111/1462-2920.14467   

Boiteau, R.M.; Hoyt, DW; Nicora, C.D.; Kinmonth-Schultz, H.A.; Ward, J.K.; Bingol, K. 2018. “Structure Elucidation of Unknown Metabolites in Metabolomics by Combined NMR and MS/MS Prediction.” Metabolites 2018, 8(1), 8; PNNL-SA-132082 doi:10.3390/metabo8010008. --- Journal Cover - http://www.mdpi.com/2218-1989/8/1  

Kang D., Z.E. Ilhan, N.G. Isern, D.W. Hoyt, D.P. Howsmon, M. Shaffer, and C. Lozupone, et al. 2018. "Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders." Anaerobe 49. PNNL-SA-127135. doi:10.1016/j.anaerobe.2017.12.007 

Kothandaraman J., R.A. Dagle, V. Dagle, S.D. Davidson, E.D. Walter, S.D. Burton, and D.W. Hoyt, et al. 2018. "Condensed-Phase Low Temperature Heterogeneous Hydrogenation of CO2 to Methanol." Catalysis Science & Technology 8, no. 19:5098-5103. PNNL-SA-133245. doi:10.1039/C8CY00997J 

Roy Chowdhury T., L.M. Bramer, D.W. Hoyt, Y. Kim, T.O. Metz, L. McCue, and H.L. Diefenderfer, et al. 2018. "Temporal dynamics of CO2 and CH4 loss potentials in response to rapid hydrological shifts in tidal freshwater wetland soils." Ecological Engineering 114. PNNL-SA-123359. doi:10.1016/j.ecoleng.2017.06.041 

Solden, L.M.; Naas AE; Roux, S.; Daly, R.A.; Collins, W.B.; Nicora, C.D.; Purvine, S.O.; Hoyt, D.W.; Schuckel J.; Joergensen, B.; Willats W.; Spalinger D.E.; Firkins JL; Lipton M.S.; Sullivan M.B.; Pope P.B.; Wrighton, K.C. 2018. “Interspecies cross-feedings orchestrate carbon degradation in the rumen ecosystem.” Nature Microbiology 3, 1274–1284. PNNL-SA-131180  doi.org/10.1038/s41564-018-0225-4   

Walter E.D., L. Qi, A. Chamas, H.S. Mehta, J.A. Sears, S.L. Scott, and D.W. Hoyt. 2018. "Operando MAS NMR Reaction Studies at High Temperatures and Pressures." Journal of Physical Chemistry C 122, no. 15:8209-8215. PNNL-SA-130852. doi:10.1021/acs.jpcc.7b11442 

Journal Cover – 04/19/2018  jc.pub.acs/122/15  PNNL-SA-130852 

2017 

Angle J., T.A. Morin, L. Solden, A.B. Narrowe, G.J. Smith, M. Borton, and C. Rey-Sanchez, et al. 2017. "Methanogenesis in oxygenated soils is a substantial fraction of wetland methane emissions." Nature Communications 8. PNNL-SA-125731. doi:10.1038/s41467-017-01753-4 

Booker A.E., M. Borton, R. Daly, S. Welch, C.D. Nicora, D.W. Hoyt, and T. Wilson, et al. 2017. "Sulfide Generation by Dominant Halanaerobium Microorganisms in Hydraulically Fractured Shales." mSphere 2. PNNL-SA-128950. doi:10.1128/mSphereDirect.00257-17 

Bowers G.M., H.T. Schaef, J.S. Loring, D.W. Hoyt, S.D. Burton, E.D. Walter, and R.J. Kirkpatrick. 2017. "Role of Cations in CO2 Adsorption, Dynamics, and Hydration in Smectite Clays Under in situ Supercritical CO2 Conditions." Journal of Physical Chemistry C 121, no. 1:577-592. PNNL-SA-122523. doi:10.1021/acs.jpcc.6b11542 

Dalcin Martins P., D.W. Hoyt, S. Bansal, C. Mills, M.M. Tfaily, B.A. Tangen, and R.G. Fincchiaro, et al. 2017. "Abundant carbon substrates drive extremely high sulfate reduction rates and methane fluxes in Prairie Pothole Wetlands." Global Change Biology 23, no. 8:3107-3120. PNNL-SA-120033. doi:10.1111/gcb.13633 

Ilhan Z.E., J.K. DiBaise, N.G. Isern, D.W. Hoyt, A.K. Marcus, D. Kang, and M. Crowell, et al. 2017. "Distinctive microbiomes and metabolites linked with weight loss after gastric bypass, but not gastric banding." The ISME Journal 11, no. 9:2047-2058. PNNL-SA-119449. doi:10.1038/ismej.2017.71 

Jaegers, N.R.; Hu MY, Hoyt DW, Wang Y, and Hu JZ. 2017 "Development and application of in-situ high-temperature, high-pressure magic angle spinning NMR" Modern Magnetic Resonance, 2nd Edition. Pp.1-19. Editor: Graham A. Webb.   Book Chapter. PNNL-SA-127762 DOI: 10.1007/978-3-319-28275-6_93-1 

Ok S., D.W. Hoyt, A. Andersen, J. Sheets, S. Welch, D.R. Cole, and K.T. Mueller, et al. 2017. "Surface Interactions and Confinement of Methane: A High Pressure Magic Angle Spinning NMR and Computational Chemistry Study." Langmuir 33, no. 6:1359-1367. PNNL-SA-123185. doi:10.1021/acs.langmuir.6b03590 

Qi L., R. Alamillo, W.A. Elliott, A. Andersen, D.W. Hoyt, E.D. Walter, and K. Han, et al. 2017. "Operando solid-state NMR observations of solvent-mediated adsorption-reaction of carbohydrates in zeolites." ACS Catalysis 7, no. 5:3489-3500. PNNL-SA-119548. doi:10.1021/acscatal.7b01045 

Schaef H.T., N. Loganathan, G.M. Bowers, R.J. Kirkpatrick, A.O. Yazaydin, S.D. Burton, and D.W. Hoyt, et al. 2017. "Tipping Point for Expansion of Layered Aluminosilicates in Weakly Polar Solvents: Supercritical CO2." ACS Applied Materials & Interfaces 9, no. 42:36783-36791. PNNL-SA-127664. doi:10.1021/acsami.7b10590 

Solden L., D.W. Hoyt, W.B. Collins, J.E. Plank, R. Daly, E. Hildebrand, and T.J. Beavers, et al. 2017. "New roles in hemicellulosic sugar fermentation for the uncultivated Bacteroidetes family BS11." The ISME Journal 11, no. 3:691-703. PNNL-SA-115562. doi:10.1038/ismej.2016.150 

White R.A., A. Rivas-Ubach, M.I. Borkum, M. Koberl, A. Bilbao Pena, S.M. Colby, and D.W. Hoyt, et al. 2017. "The state of rhizospheric science in the era of multi-omics: A practical guide to omics technologies." Rhizosphere 3, no. 2:212-221. PNNL-SA-124859. doi:10.1016/j.rhisph.2017.05.003 

2016 

Daly R., M.A. Borton, M.J. Wilkins, D.W. Hoyt, D.J. Kountz, R. Wolfe, and S. Welch, et al. 2016. "Microbial metabolisms in a new 2.5 km deep ecosystem created by hydraulic fracturing in shales." Nature Microbiology 1, no. 10:Article No. 16146. PNNL-SA-115522. doi:10.1038/nmicrobiol.2016.146 

Walker L.R., D.W. Hoyt, S. Walker, J.K. Ward, C.D. Nicora, and A.K. Bingol. 2016. "Unambiguous Metabolite Identification in High-throughput Metabolomics by Hybrid 1D 1H NMR/ESI MS1 Approach." Magnetic Resonance in Chemistry 54, no. 12:998-1003. PNNL-SA-117020. doi:10.1002/mrc.4503 

2015 

Jung H., K. Carroll, S. Kabilan, D.J. Heldebrant, D.W. Hoyt, L. Zhong, and T. Varga, et al. 2015. "Stimuli-Responsive/Rheoreversible Hydraulic Fracturing Fluids as a Greener Alternative to Support Geothermal and Fossil Energy Production." Green Chemistry 17, no. 5:2799-2812. PNNL-SA-106027. doi:10.1039/c4gc01917b 

Jung, HB, H Shao, DJ Heldebrant, S Niraj, T Varga, D Hoyt, S Kabilan, L Zhong, A Bonneville, W Um, KC Carroll, J Holladay, and CA Fernandez. 2015. “Stimuli-Responsive/Rheoreversible Hydraulic Fracturing Fluids for Enhanced Geothermal Systems” Proceedings World Geothermal Congress, 19- 25. 

2014 

Bowers G.M., D.W. Hoyt, S.D. Burton, B.O. Ferguson, T. Varga, and R.J. Kirkpatrick. 2014. "In Situ 13C and 23Na Magic Angle Spinning NMR Investigation of Supercritical CO2 Incorporation in Smectite-Natural Organic Matter Composites." Journal of Physical Chemistry C 118, no. 7:3564-3573. PNNL-SA-99489. doi:10.1021/jp410535d 

Wilkins M.J., D.W. Hoyt, M.J. Marshall, P.A. Alderson, A.E. Plymale, L.M. Markillie, and A.E. Tucker, et al. 2014. "CO2 exposure at pressure impacts metabolism and stress responses in the model sulfate-reducing bacterium Desulfovibrio vulgaris strain Hildenborough." Frontiers in Microbiology 5. PNNL-SA-103791. doi:10.3389/fmicb.2014.00507 

2013 

Feng J., J.Z. Hu, S.D. Burton, and D.W. Hoyt. 2013. "High Resolution Magic Angle Spinning 1H-NMR Metabolic Profiling of Nanoliter Biological Tissues at High Magnetic Field." Chinese Journal of Magnetic Resonance 30, no. 1:1-11. PNNL-SA-89007. 

Loring J.S., H.T. Schaef, C.J. Thompson, R.V. Turcu, Q.R. Miller, J. Chen, and J.Z. Hu, et al. 2013. "Clay hydration/dehydration in dry to water-saturated supercritical CO2: Implications for caprock integrity." Energy Procedia 37. PNNL-SA-91508. doi:10.1016/j.egypro.2013.06.463 

Miller Q., C.J. Thompson, J.S. Loring, C.F. Windisch, M.E. Bowden, D.W. Hoyt, and J.Z. Hu, et al. 2013. "Insights into Silicate Carbonation Processes in Water-Bearing Supercritical CO2 Fluids." International Journal of Greenhouse Gas Control 15. PNNL-SA-89916. doi:10.1016/j.ijggc.2013.02.005 

Turcu R.V., D.W. Hoyt, K.M. Rosso, J.A. Sears, J.S. Loring, A.R. Felmy, and J.Z. Hu. 2013. "Rotor Design for High Pressure Magic Angle Spinning Nuclear Magnetic Resonance." Journal of Magnetic Resonance 226. PNNL-SA-88703. doi:10.1016/j.jmr.2012.08.009 

2012 

Hu J.Z., J.A. Sears, H.S. Mehta, J.J. Ford, J. Kwak, K. Zhu, and Y. Wang, et al. 2012. "A Large Sample Volume Magic Angle Spinning Nuclear Magnetic Resonance Probe for In-Situ Investigations with Constant Flow of Reactants." Physical Chemistry Chemical Physics. PCCP 14, no. 7:2137-2143. PNNL-SA-82533. doi:10.1039/c1cp22692d 

Loring J.S., H.T. Schaef, R.V. Turcu, C.J. Thompson, Q. Miller, P.F. Martin, and J.Z. Hu, et al. 2012. "In Situ Molecular Spectroscopic Evidence for CO2 Intercalation into Montmorillonite in Supercritical Carbon Dioxide." Langmuir 28, no. 18:7125-7128. PNNL-SA-86500. doi:10.1021/la301136w 

2011 

Ahring B.K., N.S. Baliga, J.R. Frederickson, S. Kaplan, H.B. Pakrasi, J.G. Pounds, and I. shah, et al. 2011. Biological Interactions and Dynamics Science Theme Advisory Panel (BID-STAP). PNNL-20717. Richland, WA: Pacific Northwest National Laboratory. Biological Interactions and Dynamics Science Theme Advisory Panel (BID-STAP) 

Brown G.E., A. Chaka, D.K. Shuh, E.E. Roden, C.J. Werth, N.J. Hess, and A.R. Felmy, et al. 2011. EMSL Geochemistry, Biogeochemistry and Subsurface Science-Science Theme Advisory Panel Meeting. PNNL-20601. Richland, WA: Pacific Northwest National Laboratory. EMSL Geochemistry, Biogeochemistry and Subsurface Science-Science Theme Advisory Panel Meeting 

Campbell C.T., A.K. Datye, G.A. Henkelman, R.F. Lobo, W.F. Schneider, L.D. Spicer, and W.T. Tysoe, et al. 2011. EMSL and Institute for Integrated Catalysis (IIC) Catalysis Workshop. PNNL-20426. Richland, WA: Pacific Northwest National Laboratory. EMSL and Institute for Integrated Catalysis (IIC) Catalysis Workshop 

Hoyt D.W., R.V. Turcu, J.A. Sears, K.M. Rosso, S.D. Burton, A.R. Felmy, and J.Z. Hu. 2011. "High-pressure Magic Angle Spinning Nuclear Magnetic Resonance." Journal of Magnetic Resonance 212, no. 2:378-385. PNNL-SA-80681. doi:10.1016/j.jmr.2011.07.019 

Hoyt D.W., R.V. Turcu, J.A. Sears, K.M. Rosso, S.D. Burton, J. Kwak, and A.R. Felmy, et al. 2011. "IN SITU MAGIC ANGLE SPINNING NMR FOR STUDYING GEOLOGICAL CO(2) SEQUESTRATION." In 241st National Meeting and Exposition of the American Chemical Society, March 27-31, 2011, Anaheim, California, 241, 245-Fuel. Washington Dc:American Chemical Society. PNNL-SA-77039. 

Kwak J., J.Z. Hu, R.V. Turcu, K.M. Rosso, E.S. Ilton, C.M. Wang, and J.A. Sears, et al. 2011. "The Role of H2O in the Carbonation of Forsterite in Supercritical CO2." International Journal of Greenhouse Gas Control 5, no. 4:1081-1092. PNNL-SA-76665. doi:10.1016/j.ijggc.2011.05.013 

Teklemichael S.T., W. Oo, M. Matthew, E.D. Walter, and D.W. Hoyt. 2011. "Acceptors in ZnO nanocrystals." Applied Physics Letters 98, no. 23:Article No. 232112. PNNL-SA-79839. doi:10.1063/1.3598411 

White M.D., B.P. McGrail, H.T. Schaef, J.Z. Hu, D.W. Hoyt, A.R. Felmy, and K.M. Rosso, et al. 2011. "Multiphase Sequestration Geochemistry: Model for Mineral Carbonation." Energy Procedia 4. PNNL-SA-74658. doi:10.1016/j.egypro.2011.02.472 

2010 

Kwak J., J.Z. Hu, D.W. Hoyt, J.A. Sears, C.M. Wang, K.M. Rosso, and A.R. Felmy. 2010. "Metal Carbonation of Forsterite in Supercritical CO2 and H2O Using Solid State 29Si, 13C NMR Spectroscop." Journal of Physical Chemistry C 114, no. 9:4126 - 4134. PNNL-SA-68897. doi:10.1021/jp1001308 

2009 

Chen B., X. Ren, T. Neville, W. Jerome, D.W. Hoyt, D.L. Sparks, and G. Ren, et al. 2009. "Apolipoprotein AI tertiary structures determine stability and phospholipid-binding activity of discoidal high-density lipoprotein particles of different sizes." Protein Science 18, no. 5:921-935. PNNL-SA-56783. doi:10.1002/pro.101 

Hu J.Z., J.A. Sears, J. Kwak, D.W. Hoyt, Y. Wang, and C.H. Peden. 2009. "An Isotropic Chemical Shift-Chemical Shift Anisotropic Correlation Experiment Using Discrete Magic Angle Turning." Journal of Magnetic Resonance 198, no. 1:105-110. PNNL-SA-63634. doi.org/10.1016/j.jmr.2009.01.027  

2008 

Briknarova K., X. Zhou, A.C. Satterthwait, D.W. Hoyt, K.R. Ely, S. Huang, and S. Huang. 2008. "Structural Studies of the SET Domain from RIZ1 Tumor Suppressor." Biochemical and Biophysical Research Communications 366, no. 3:807-813. PNNL-SA-56117. doi:10.1016/j.bbrc.2007.12.034 

2007 

Ren X., Y. Yang, T. Neville, T. Neville, D.W. Hoyt, D.L. Sparks, and J. Wang. 2007. "A complete backbone spectral assignment of human apolipoprotein AI on a 38 kDa preßHDL (Lp1-AI) particle." Biomolecular NMR Assignments 1, no. 1:69-71. PNNL-SA-53926. doi:10.1007/s12104-007-9020-5  

Smirnov S., N.G. Isern, Z.G. Jiang, D.W. Hoyt, and C.J. Mcknight. 2007. "The Isolated Sixth Gelsolin Repeat and Headpiece Domain of Villin Bundle F-Actin in the Presence of Calcium and Are Linked by a 40-Residue Unstructured Sequence." Biochemistry 46, no. 25:7488-7496. PNNL-SA-55624. doi:10.1021/bi700110v 

Yang Y., D.W. Hoyt, and J. Wang. 2007. "A Complete NMR Spectral Assignment of the Lipid-free Mouse Apolipoprotein A-I (ApoAI) C-terminal Truncation Mutant, ApoAI(1-216)." Biomolecular NMR Assignments 1, no. 1:109-111. PNNL-SA-53927. doi:10.1007/s12104-007-9031-2 

2006 

Brzovic P.S., A.V. Lissounov, D. Christensen, D.W. Hoyt, and R.E. Klevit. 2006. "A UbcH5/Ubiquitin Noncovalent Complex is Required for Processive BRCA1-Directed Ubiquitination." Molecular Cell 21, no. 6:873-880. PNNL-SA-48810. DOI:  10.1016/j.molcel.2006.02.008 

2005 

Briknarova K., F. Nasertorabi, M.L. Havert, E. Eggleston, D.W. Hoyt, C. Li, and A.J. Olson, et al. 2005. "The Serine-rich Domain from Crk-associated Substrate (p130Cas) is a Four-helix Bundle." Journal of Biological Chemistry 280, no. 23:21908-21914. PNNL-SA-45324. doi: 10.1074/jbc.M501258200 

Xu C., A. Sivashanmugam, D.W. Hoyt, and J. Wang. 2005. "A Complete Backbone Assignment of the Apolipoprotein E LDL Receptor Binding Domain [Letter to the Editor]." Journal of Biomolecular NMR 32, no. 2:177. PNNL-SA-44749. doi:10.1007/s10858-005-6729-2 

2004 

Hoyt D.W., S.D. Burton, M.R. Peterson, J.D. Myers, and G. Chin. 2004. "Expanding Your Laboratory by Accessing Collaboratory Resources." Analytical and Bioanalytical Chemistry 378, no. 6:1408-1410. PNNL-SA-39416. DOI: 10.1007/s00216-003-2428-6   

2003 

Briknarova K., M. Akermann, D.W. Hoyt, E. Ruoslahti, and K.R. Ely. 2003. "Anastellin, an FN3 Fragment with Fibronectin Polymerization Activity, Resembles Amyloid Fibril Precursors." Journal of Molecular Biology 332, no. 1:205-215. PNNL-SA-38930. DOI: 10.1016/S0022-2836(03)00890-8 

Kreishman-Detrick M., C. Egile, D.W. Hoyt, J.J. Ford, R. Li, and M.K. Rosen. 2003. "NMR analysis of methyl groups at 100-500 kDa: model systems and Arp2/3 complex." Biochemistry 42, no. 28:8579-8586. PNNL-SA-39415. DOI: 10.1021/bi034536j 

Lowry D.F., D.W. Hoyt, F.A. Khazi, J.R. Bagu, A.G. Lindsey, and D.M. Wilson Iii. 2003. "Investigation of the role of the histidine-aspartate pair in the human exonuclease III-like abasic endonuclease, Ape1." Journal of Molecular Biology 329, no. 2:311-322. PNNL-SA-40864. DOI: 10.1016/S0022-2836(03)00382-6 

Lowry D.F., D.W. Hoyt, F.A. Khazi, J.R. Bagu, A.G. Lindsey, and D.M. Wilson. 2003. "Investigation of the Role of the Histidine-Aspartate Pair in the Human Exonuclease III-like Abasic Endonuclease, Ape1." Journal of Molecular Biology 329, no. 2:311-322. PNNL-SA-36499. DOI: 10.1016/S0022-2836(03)00382-6 

2002 

Briknarova K., S. Takayama, S. Homma, K. Baker, E. Cabezas, D.W. Hoyt, and Z. Li, et al. 2002. "BAG4/SODD Protein Contains a Short BAG Domain." Journal of Biological Chemistry 277, no. 34:31172-31178. PNNL-SA-36503. doi: 10.1074/jbc.M202792200 

Chin G., J.D. Myers, and D.W. Hoyt. 2002. "Social Networks in the Virtual Science Laboratory." Communications of the ACM 45, no. 8:87-92. PNNL-SA-35242. doi>10.1145/545151.545156 

McInnes, E.; DW Hoyt, M O'Connor-McCourt, and BD Sykes.  2002. “Characterization of Transforming Growth Factor-a Binding to Epidermal Growth Factor Receptor Through NMR Structure Determination and NOE Analysis Methods.” Peptides Frontier of Peptide Science: Proceedings of the Fifteenth American Peptide Symposium , Tam and Kaumaya (Ed.), Springer Netherlands. DOI:10.1007/0-306-46862-X_158  

2001 

Briknarova K., S. Takayama, L. Brive, M.L. Havert, D.A. Knee, J. Velasco, and S. Homma, et al. 2001. "Structural Analysis of BAG1 Cochaperone and Its Interactions with Hsc70 Heat Shock Protein." Nature Structural Biology 8, no. 4:349-352. PNNL-SA-33922. doi:10.1038/86236 

Bryant P.L., C. Harwell, A.A. Mrse, E.F. Emery, Z. Gan, T. Caldwell, and A.P. Reyes, et al. 2001. "Structural Characterization of MAO and Related Aluminum Complexes. 1. Solid-State 27 Al NMR with Comparison to EFG Tensors from ab Initio Molecular Orbital Calculations." Journal of the American Chemical Society 123. PNNL-SA-33924. DOI: 10.1021/ja011092a 

Brzovic P.S., P. Rajagopal, D.W. Hoyt, M. King, and R.E. Klevit. 2001. "Structure of a BRCA1/BARD1 Complex: a Heterodimeric RING-RING Interaction." Nature Structural Biology 8, no. 10:833-837. PNNL-SA-34960. doi:10.1038/nsb1001-833 

2000 

Liu K., H.S. Cho, D.W. Hoyt, T.N. Nguyen, P. Olds, J.W. Kelly, and D. Wemmer. 2000. "Deuterium-proton Exchange on the Native Wild-type Transthyretin Tetramer Identifies the Stable Core of the Individual Subunits and Indicates Mobility at the Subunit Interface." Journal of Molecular Biology 303, no. 4:555-565. PNNL-SA-33925. DOI: 10.1006/jmbi.2000.4164 

1998 

Buchko, G.W.; A Rozek, DW Hoyt, RJ Cushley, and MA Kennedy. 1998. “The Use of Sodium Dodecyl Sulfate to Model the Apolipoprotein Environment Evidence for Peptide-SDS Complexes Using Pulsed-field Gradient NMR Spectroscopy.” Biochimica et Biophysica Acta.  1392:101-108. DOI: 10.1016/S0005-2760(98)00028-9