PNNL researchers developed a new computational workflow to study day-to-night gene expression dynamics of cyanobacterium in real time.

This achievement earned DIMPLES a Best Paper award at the ACM International Conference on Supercomputing 2025.

Predicting how organisms’ characteristics respond to not only their genes, but also their environments (a nascent field called predictive phenomics), is extraordinarily challenging. Researchers at PNNL are using AI to tackle that challenge.

As Laboratory Director Steve Ashby pens his last monthly column, he highlights PNNL’s accomplishments with pride and gratitude.

Researchers are uncovering the secrets of a fast-acting molecular messaging network that helps determine how the genetic code plays out.

Understanding molecular modifications of proteins in the red yeast could help scientists re-engineer the organism’s phenotype.

Three research teams led by PNNL organizers achieve journal publications following the Mathematics Research Communities program.

PNNL showcased its expertise in AI, machine learning, and related domains at the International Conference on Machine Learning.

Expanding the nation’s largest wind power plant time series database; helping grid planners navigate a resilient energy future with better data.

Continued studies will deepen scientists’ understanding of virus-host interactions at the molecular level and also pave the way for developing better drugs to fight emerging viruses.

Flexible, high-throughput proteomics approach identifies protein modifications related to pancreatic stress and insulin production.

PNNL researchers have published their paper, “Introducing Molecular Hypernetworks for Discovery in Multidimensional Metabolomics Data,” in the Journal of Proteome Research.

Scientists uncover how cyanobacteria's circadian cycle controls carbon and energy metabolism, increasing carbon dioxide-to-bioproducts yields.

Scientists map how transitions from day to night control gene regulatory networks in cyanobacteria, revealing key orchestrators of metabolic switching.

PNNL is hosting a scientific conference focused directly on understanding and predicting the collection of an organism’s traits.

Researchers can now quantify uncertainty in trained AI models aimed at solving difficult chemistry, biology and materials science problems.

Researchers have created an algorithm that slashes the calculations necessary to prepare and customize data for quantum computing.

Circadian rhythms of blue-green microbes offer new window into predictive phenomics—how to predict and control the traits of an organism.

Scientists are exploring how web search engine technology might also keep the lights on, the water running and the trains moving.

This week at AAAS, PNNL scientists discuss phenomics and the factors that influence DNA instructions to bring about the world around us.