Researchers at PNNL are pursuing new approaches to understand, predict and control the phenome—the collection of biological traits within an organism shaped by its genes and interactions with the environment.

Researchers developed a robust, cost-effective, and easy-to-use cap-based technique for spatial proteome mapping, addressing the lack of accessible proteomics technologies for studying tissue heterogeneity and microenvironments.

Three PNNL researchers will receive five continuous years of funding for projects through highly competitive DOE Early Career Research Program awards.

Ljiljana Paša-Tolić, a PNNL fellow, is the recipient of the 2024 International Mass Spectrometry Foundation’s Jochen Franzen Award. 

New research sheds light on the biomolecular dangers of night shift work.

PNNL contributes to a nationwide research consortium investigating the molecular mechanisms triggered by endurance training.

A streamlined informatics workflow that automatically processes complex data and provides the locations of double bonds in lipids.

Hi-C metagenomics-informed phage-host infection networks detected in soil pre- and post-drying.

PNNL scientists took thousands of measurements of firefighters in training to learn more about how the body responds to vigorous exercise.

This study profiled the 24-hour rhythmicity in bile salt hydrolase enzyme activity using simple fluorescence assay and the results showed that this rhythmicity is influenced by feeding patterns of the host.

Joshua Adkins and Jamie Lo will lead PMedIC, Pacific Northwest National Laboratory and Oregon Health & Science University’s joint research institute.

New research from PNNL and Washington State University collaborators connects the microbiome in the gut to circadian rhythms, suggesting a role for the microbiome as an internal regulator.

Metabolomics analysis revealed differences in metabolome profiles for two distinct modes of fungal wood decay.

Advanced proteomic analysis tools dig deep into human blood plasma to understand the molecular nature of advanced alcoholic disease.

PNNL Biomedical Scientist Geremy Clair has taken on new roles as an editor for two journals; Frontiers In Cellular And Infection Microbiology and Frontiers In Molecular Biosciences.

Data from increasingly complex mass spectrometry instruments met with adaptable data analysis solution.

Study highlights microbiome’s role in regulating xenobiotic metabolism.

The nested nanoPOTS chip is the next generation of technology developed at PNNL to prepare single cells for proteomics.

Customized molecular tools identify specific microbial functions that are key to healthy people and environments.

Kristin Burnum-Johnson presented at two virtual events in June on proteome mapping.