Researchers at PNNL are pursuing new approaches to understand, predict and control the phenome—the collection of biological traits within an organism shaped by its genes and interactions with the environment.

Researchers developed a robust, cost-effective, and easy-to-use cap-based technique for spatial proteome mapping, addressing the lack of accessible proteomics technologies for studying tissue heterogeneity and microenvironments.

Ljiljana Paša-Tolić, a PNNL fellow, is the recipient of the 2024 International Mass Spectrometry Foundation’s Jochen Franzen Award. 

PNNL contributes to a nationwide research consortium investigating the molecular mechanisms triggered by endurance training.

Models have identified a new source of anthropogenic emissions driving the observed weakening of the Atlantic Meridional Overturning Circulation.

PNNL scientists took thousands of measurements of firefighters in training to learn more about how the body responds to vigorous exercise.

Less pollution and the odd shapes of snow grains as they pack together should help cut the decline of snowpack later this century.

In a new paper, researchers point to three major efforts where the biggest climate mitigation gains stand to be realized: ramping up carbon dioxide removal, reigning in non-carbon dioxide emissions and halting deforestation.

A new discovery by PNNL researchers has illuminated a previously unknown key mechanism that could inform the development of new, more effective catalysts for abating NOx emissions from combustion-engines burning diesel or low carbon fuel.

This study profiled the 24-hour rhythmicity in bile salt hydrolase enzyme activity using simple fluorescence assay and the results showed that this rhythmicity is influenced by feeding patterns of the host.

Joshua Adkins and Jamie Lo will lead PMedIC, Pacific Northwest National Laboratory and Oregon Health & Science University’s joint research institute.

New research from PNNL and Washington State University collaborators connects the microbiome in the gut to circadian rhythms, suggesting a role for the microbiome as an internal regulator.

Advanced proteomic analysis tools dig deep into human blood plasma to understand the molecular nature of advanced alcoholic disease.

PNNL Biomedical Scientist Geremy Clair has taken on new roles as an editor for two journals; Frontiers In Cellular And Infection Microbiology and Frontiers In Molecular Biosciences.

The Co-Optimization of Fuels & Engines initiative recently outlined six years of research in a findings and impact report.

Study highlights microbiome’s role in regulating xenobiotic metabolism.

PNNL catalysis expert Yong Wang has assumed an associate editor role for the Chemical Engineering Journal.

A multi-institution team of researchers has developed a palladium-based catalyst that could clean emissions from natural gas engines.

PNNL is rock solid on carbon storage, building on successful demonstration in eastern Washington.

The nested nanoPOTS chip is the next generation of technology developed at PNNL to prepare single cells for proteomics.