Integrating experiments and modeling show how a fungal exudate-inspired substrate mixture elicits an emergent growth phenotype and metabolic responses in Pseudomonas putida.

By selectively stabilizing either a right- or left-handed helical pose of its substrate, an enzyme tunes the final product.

Uncovered how the choice of carbon source influences the stress tolerance, redox balance, and regulatory responses of yeast, which can help provide resilience against scale-up challenges.

Five PNNL innovations earned 2026 R&D 100 Awards for advances in biotechnology, manufacturing, critical minerals, and nuclear security.

New partnership agreement to focus on AI, robotics, and advanced energy systems.

A research team from Pacific Northwest National Laboratory used machine reasoning to schedule scientific workflows while guaranteeing quality of service (QoS).

Study shows the advantages of top-town proteomics for characterizing histones.

At the summit, PNNL engaged with partners and investors, highlighting seven projects that accelerate the deployment of new energy technologies.

David Wunschel, a chemist and Laboratory Fellow, participated on a panel focused on how emerging technologies are transforming CBRN defense, detection, and response across military and government operations.

Integrating new functions into a genome-scale model enabled researchers to simulate and experimentally validate viral hijacking pathways.

A microbial community expresses a phenotype of interest ~20 percent higher than the sum of each member species.

Structural proteomics reveal how cyanobacteria adapt to changing light.

Secretary Wright visited PNNL's campus in Richland, Washington, late last year to meet with innovators in chemistry, biology, computing, and more.

Darío Gil, DOE's Undersecretary for Science, makes his inaugural visit to PNNL.

Researchers use multiomics to confirm role of lipid synthesis during infection, leading to model of how to restrict virus replication.

PNNL researchers Daniel Deng and Yehia Ibrahim join the 2025 class of National Academy of Inventors Fellows.

In a recent study, PNNL researchers found that noncrystalline mineral surfaces can bind microbial residues to build soil organic matter.

Capturing protein structural changes in host cells exposes vulnerabilities exploited by viruses to hijack cellular machinery.

Distributed science is thriving at PNNL, where scientists share data and collaborate with researchers around the world to increase the impact of the work.

From developing new energy storage materials to revealing patterns of Earth’s complex systems, studies led by PNNL researchers are recognized for their innovation and influence.