Integrating experiments and modeling show how a fungal exudate-inspired substrate mixture elicits an emergent growth phenotype and metabolic responses in Pseudomonas putida.

Uncovered how the choice of carbon source influences the stress tolerance, redox balance, and regulatory responses of yeast, which can help provide resilience against scale-up challenges.

Five PNNL innovations earned 2026 R&D 100 Awards for advances in biotechnology, manufacturing, critical minerals, and nuclear security.

Study shows the advantages of top-town proteomics for characterizing histones.

Replacing commercial acid with acidic waste enables researchers to improve nickel extraction efficiency, lower projected costs, and improve process economics.

A microbial community expresses a phenotype of interest ~20 percent higher than the sum of each member species.

Structural proteomics reveal how cyanobacteria adapt to changing light.

Secretary Wright visited PNNL's campus in Richland, Washington, late last year to meet with innovators in chemistry, biology, computing, and more.

Researchers use multiomics to confirm role of lipid synthesis during infection, leading to model of how to restrict virus replication.

PNNL researchers Daniel Deng and Yehia Ibrahim join the 2025 class of National Academy of Inventors Fellows.

Capturing protein structural changes in host cells exposes vulnerabilities exploited by viruses to hijack cellular machinery.

PNNL researchers developed a new computational workflow to study day-to-night gene expression dynamics of cyanobacterium in real time.

Understanding molecular modifications of proteins in the red yeast could help scientists re-engineer the organism’s phenotype.

Researchers have developed the first coastal transport model for microplastics to understand how particles move in waterways and coastal currents.

Continued studies will deepen scientists’ understanding of virus-host interactions at the molecular level and also pave the way for developing better drugs to fight emerging viruses.

Flexible, high-throughput proteomics approach identifies protein modifications related to pancreatic stress and insulin production.

Researchers at PNNL advised elementary and middle school student teams with their problem-solving research for the FIRST® LEGO® League robotics competitions.

Scientists uncover how cyanobacteria's circadian cycle controls carbon and energy metabolism, increasing carbon dioxide-to-bioproducts yields.

Scientists map how transitions from day to night control gene regulatory networks in cyanobacteria, revealing key orchestrators of metabolic switching.