Additive manufacturing is a powerful tool to manufacture new and novel separation equipment including hardware for distillation applications. Distillation accounts for most of the industrial separations that exist today and consumes 40% of energy used in the process industry. Here xenon enrichment is realized using a microchannel distillation device that incorporates an additively manufactured structure capable of wicking liquid along the axial length of the device. The concept involves thin ( < 500 mm) porous materials that are additively manufactured out of metal materials that form the liquid path and have adjacent larger flow channels for counter-current vapor flow. Dry air at up to 30 L/min is liquified using a cryocooler, i.e. condenser, and liquid flows through the liquid wicks and into a reboiler where components with lower boiling points are vaporized and flow back through the large vapor channels back towards the condenser. The entire distillation system is insulated in a vacuum can to provide an adiabatic operation which is essential to successful distillation. Mass transfer occurs between the two phases that flow in a vertical, counter-current direction. Gas species which have higher boiling points, such as xenon, in comparison to the main component of air, i.e. nitrogen, are concentrated in the liquid phase in the reboiler. The distillation column here is < 12 inches tall and is the first additively manufactured distillation device used for xenon enrichment experiments. The technology opens the door to further process intensification of distillation devices whereby new geometries are realized and enhanced mass and heat transfer is achieved.