This invention disclosure presents a method and system that exploits the impact that Endocrine Disrupting Chemicals (EDCs) exert on gene products through receptor binding to refine the predictive power of Quantitative Structure-Activity Relationships (QSAR) modeling in identifying EDCs and to discover biomarkers associated with identified EDCs. The approach focuses on two main tasks: . Develop a framework to assess the toxicity of chemicals in terms of their impact at the gene/protein level . Use the impact of chemicals at the gene/protein level to identify biomarkers.