ACONITIC ACID EXPORTER (AEXA) INCREASES ORGANIC ACID PRODUCTION IN ASPERGILLUS (iEdison No. 0685901-20-00430)

Patent ID: 9940 | Patent Number 11,873,523 | Status: Granted

Abstract

Multi-omics analysis on membrane proteins in both wild type A. pseudoterreus and cad deletion stains led to identification of a specific exporter responsible for aconitic acid high production in the cad deletion platform. Overexpression of this single exporter increased aconitc acid titer by 5 fold, from 10g/L to 50g/L.

Application Number

17/347,109

Inventors

Hofstad,Beth A
Dai,Ziyu
Magnuson,Jon K
Deng,Shuang
Kim,Joonhoon
Pomraning,Kyle R

Market Sector

Energy Production and Efficiency
Chemistry and Catalysts
Biological Sciences and Omics