ACONITIC ACID EXPORTER (AEXA) INCREASES ORGANIC ACID PRODUCTION IN ASPERGILLUS (iEdison No. 0685901-20-0043)

Patent ID: 10788 | Patent Number 12,338,480 | Status: Granted

Abstract

Multi-omics analysis on membrane proteins in both wild type A. pseudoterreus and cad deletion stains led to identification of a specific exporter responsible for aconitic acid high production in the cad deletion platform. Overexpression of this single exporter increased aconitc acid titer by 5 fold, from 10g/L to 50g/L.

Application Number

18/493,590

Inventors

Deng,Shuang
Magnuson,Jon K
Dai,Ziyu
Hofstad,Beth A
Kim,Joonhoon
Pomraning,Kyle R

Market Sector

Energy Production and Efficiency
Chemistry and Catalysts
Biological Sciences and Omics