PROCESS FOR MAKING CARBON-BASED NANO-RODS FROM SWITCHABLE IONIC LIQUIDS AND DEVICES AND PROCESSES INCORPORATING SAME
A method of making carbon-based nano-rods from switchable ionic liquids (SWIL) that incorporates the SWIL is disclosed. Resulting nano-rods provide adsorption and spontaneous desorption of water at selected relative humidity values that find use in selected applications and devices.
JOINTS WITH HIGH VELOCITY INDUCED METALLURGICAL BONDS (iEdison No. 0685901-22-0035)
Due to the melting point differential and solubility issues, conventional resistance spot welding is not feasible for many multi-material applications. Resistance spot welding is not feasible for multimaterial applications owing to the difference in melting points and solubility issue. Riveting and more specifically self pierce riveting utilizes coated boron steel self-piercing rivets. They have: ? Corrosion issues due to difference in galvanic potentials especially between steel and magnesium ? Issues with end of life recycling challenge ? the application or SPR's introduce significant change in the body shop operations which add additional cost and lost production when existing operations are utilized Solution/Invention: Using the high velocity riveting system we effectively eliminated the use of rivet to form a metallurgical bond avoiding galvanic corrosion, cost and life cycle issues, with minimal impact to existing body shop operations. Other benefits: Description: Utilizes a handheld system, so it could be used for any robot using resistance spot welding (low capital investment to implement and doesn't require significant changes to manufacturing line) Not using steel so less issues w/ corrosion Do not need to drill holes (reduces manual labor. steps) Recyclable(without steel rivets you have a 100% BIW recyclable)
Acoustic Transmission Devices and Process for Making and Using Same (iEdison No. 0685901-13-0021)
Acoustic tags and a process for fabrication are disclosed for identifying and tracking various hosts including inanimate and animate objects in up to three dimensions. The acoustic tags may be powered by a single power source. Tags can have an operation lifetime of up to 90 days or longer at a transmission rate of 3 seconds. The acoustic tags have an enhanced signal range that enhances detection probability when tracking the hosts.
PROBE FOR SELECTIVELY CHARACTERIZING ENZYMES INVOLVED IN XENOBIOTIC METABOLISM AND METHOD OF MAKING AND USING THE SAME (iEdison No. 0685901-17-0013)
We have developed, or have conceptual designs, for chemical probes to cover the mammalian enzyme families associated with phase 1 (oxidation) and phase 2 (conjugation) drug and xenobiotic metabolism. Our activity-based probes enable the selective characterization of any functionally active isoforms of enzymes within the superfamilies of enzymes that perform phase 1 and 2 metabolism. Specifically, these probes don't provide a readout of the total activity of an enzyme family, but instead provide the activity contribution of individual enzymes. This goes well beyond anything that is commercially available, which primarily measure total enzyme family activities. Specifically we have developed chemical probes for cytochrome P450 enzymes (phase 1), glutathione S-transferases (phase 2), epoxide hydrolases (phase 2), UDP-glucuronosyltransferases (UGTs; phase 2), sulfotransferases (phase 2), and we have conceptual designs for aldoketoreductases and NAD(P)H quinone oxidoreductases (both phase 2). See attached file on phase 1 and 2 drug metabolism. All of the chemical probes enable multimodal profiling, meaning measurements can be made by imaging, flow cytometry, and proteomics. We are currently working on ways to immobilize the probes on to glass or other resin surfaces, such that arrays of probes can be rapidly developed to broadly characterize mammalian metabolism in organ tissues and extracts (e.g. liver), or cell lines and extracts. The arrays we are developing will enable two primary measurements: (1) we will be able to rapidly profile which enzymes are involved in the metabolism of a drug or xenobiotic (e.g., a pesticide); (2) we will be able to rapidly determine the specific phase 1/2 enzymes that are inhibited or activated by a drug or xenobiotic. Important note: the probes for cytochrome P450s were originally developed and published when Aaron Wright was a postdoc at the Scripps Research Institute. They were not patented at that point. We have since published with these probes in other programs at PNNL. However, there is no publication that discusses their use in arrays for rapid characterization of metabolism or inhibition/activation by a drug or xenobiotic.