Dynamic Multiplexed Analysis Method Using Ion Mobility Spectrometer
This invention aims at high-thoughput high-sensitivity analysis of biological samples using an automated platform that encompasses LC fractionation and multiplexed IMS-TOF instrument. High sensitivity is achieved by correlating the analyte abundances from a particular fraction with the order of an encoding sequence, so as to provide the optimum use of ion trap charge capacity prior to IMS separation. Identification of the interesting features detected in the multiplexed IMS-TOF experiments with different LC fractions will be accomplished using multiplexed IMS-MS/MS approach.
METHOD AND APPARATUS FOR SPATIAL COMPRESSION AND INCREASED MOBILITY RESOLUTION OF IONS
Methods and apparatuses for ion peak compression and increasing resolution of ions are disclosed. Packets of ions are introduced into a device. A first electric field is applied for dispersing the ion packets temporally or spatially according to their mobilities. A second intermittent traveling wave is applied for regrouping or merging the dispersed ion packets into a lesser number of trapping regions with narrower peaks. The ions packets are compressed into the narrower peak regions by varying a duty cycle of the intermittent traveling wave.
ELECTRON MICROSCOPE SAMPLE INSERTION AND REMOVAL TOOL (iEdison No. 0685901-24-0104)
When a sample needs to be put into a machine for experimentation or study, the sample is affixed to an arrowhead shaped sample holder called a "Puck". The puck has a "Stem" at the back of it that attaches to/docks with a device called a "Puckulator". The puckulator is used to safely and reliably transfer these pucks in and out of machines. Its main purpose is to ensure that it will not let go of a puck until it has been properly secured into a stage. A puckulator is usually affixed to the end of a long rod and manipulated at a distance by twisting the rod to lock/unlock the puck into it's stage.(Visual demonstration can be seen in the "Puckulator Purpose Drawing" document)There has been previous designs of puckulators, however the Revision E is, in my opinion, the superior design.
SURFACE DETERMINATION SYSTEMS, THREAT DETECTION SYSTEMS AND MEDICAL TREATMENT SYSTEMS (NIH iEdison No. 0685901-20-0022, Grant No. CA227586)
This invention consists of new methods for accurately estimating the surface of the human body or objects that are scanned by active wideband microwave or millimeter-wave imaging systems. The invention improves upon the state of the art by carefully focusing the images to preserve phase information inherent in the propagation of the electromagnetic waves used to form the images, and then exploiting the fact that the phase of the reconstructed image follows the surface. This means that surfaces of constant phase in the reconstruction follow the contours of the body or target. Furthermore, if the image reconstruction is performed in an exacting manner, the surface of the body tracks the zero-phase contour precisely. The surface can therefore be estimated by forming a high-resolution image using backprojection or similar methods and then finding the surface by numerically finding the zero-phase position over a lattice of positions. High-resolution active wideband microwave and millimeter-wave imaging systems are typically formed by mechanically, or electronically scanning a transceiver over a 2D aperture. At each point in the aperture the transceiver emits a wideband signal that interacts with the target and is captured coherently by the receiver. The subsequent data are then three-dimensional consisting of two spatial axes and one frequency axis. These data can then be focused using backprojection or other similar methods. Resolution in microwave imaging is limited by diffraction in the lateral dimensions and by bandwidth in the range or depth dimension. Tracking the surface is typically done after image formation by taking the magnitude image and forming iso-surfaces, or surfaces of constant amplitude. This process causes errors in the surface estimation since it inherently assumes that brightness is related to position. A brighter zone in the image will appear closer than a dimmer zone, even if they are at the same depth. The new methods in this invention achieve high accuracy by eliminating the bias caused by the image amplitude variations and by exploiting the image phase. The image phase varies approximately 360 degrees for every half-wavelength in depth variation. The zero-phase position can be estimated to accuracies of better than a few degrees. Therefore, the surface can be estimated to small fraction of one-half wavelength. Normal methods are limited by the depth resolution, which is typically much larger than one-half wavelength.
METHOD AND APPARATUS FOR COMPRESSING IONS (NIH iEdison No. 0685901-13-0008)
The invention in general relates to methods of compressing an ion packet inside an IMS based device for achieving high IMS resolving power, while maintaining the peak resolution. When a relatively broad ion packet in gas phase, is subjected to a nonlinear potential profile with a decreasing electric drift field; the ions in the high field region move faster than the low field region resulting in peak bunching. While ions drift over a long drift section with a constant electric field of a mobility device, they separate out based on their mobilities. However, individual peaks also broaden due to diffusion. In the present method, by using non-constant electric fields (DC) the peak broadening can be overcome. Due to nonlinear potential profile, the ions in different regions move with different velocities. Therefore when applied suitably, these fields can be used to bunch together ions in a broad peak to a narrow packet. When the different mobilities are sufficiently separated, the bunching is applied locally; this processes will not negatively affect the time separation (resolution) characteristics. When applied to close mobilities or peaks not well separated, some loss in time resolution may occur. This method can be used in any general mobility device, but is particularly attractive in SLIM devices where ion transport is practically lossless, facilitates long drift lengths, provides sufficiently resolved peaks to be effectively bunched.
UNIVERSAL LIQUID SAMPLE DEVICE AND PROCESS FOR HIGH RESOLUTION TRANSMISSION ELECTRON MICROSCOPE IMAGING AND MULTIMODAL ANALYSES OF LIQUID SAMPLE MATERIALS
Liquid sample imaging devices and processes are disclosed for high resolution TEM imaging and multimodal analyses of liquid sample materials in situ under high vacuum that are compatible with standard type TEM chip membranes and TEM sample holders allowing TEM liquid sample imaging to be performed wherever a TEM instrument is accessible and at a substantially reduced cost compared to prior art systems and approaches.
Enhanced Surfaces Sampler and Process for Collection and Release of Analytes
An enhanced swipe sampler and method of making are described. The swipe sampler is made of a fabric containing selected glass, metal oxide, and/or oxide-coated glass or metal fibers. Fibers are modified with silane ligands that are directly attached to the surface of the fibers to functionalize the sampling surface of the fabric. The swipe sampler collects various target analytes including explosives and other threat agents on the surface of the sampler.
NUCLEAR REACTOR ASSEMBLIES, NUCLEAR REACTOR TARGET ASSEMBLIES, AND NUCLEAR REACTOR METHODS (iEdison No. 0685901-16-0012)
Reactor target assemblies are provided that can include a housing defining a perimeter of at least one volume and Np or Am spheres within the one volume. Reactor assemblies are provided that can include a reactor vessel and a bundle of target assemblies within the reactor vessel, at least one of the target assemblies comprising a housing defining a volume with Np or Am spheres being within the volume. Irradiation methods are also provided that can include irradiating Np or Am spheres within a nuclear reactor, then removing the irradiated spheres from the reactor and treating the irradiated spheres.
Apparatus for Synthetic Imaging of an Object
An apparatus for synthetic imaging of an object is disclosed. The apparatus includes a plurality of transmitter elements spaced apart by a first distance in a first column and a plurality of receiver elements spaced apart by a second distance in a second column. The first distance and the second distance are different. The plurality of transmitter elements is a non-integer multiple of the plurality of receiver elements, and the plurality of receiver elements is a non-integer multiple of the plurality of transmitter elements.