PNNL

Abstract

Activity descriptors are a powerful tool for the design of catalysts than can efficiently utilize H2 with minimal energy losses. In this study, we develop the use of hydricity and H- self-exchange rates as thermodynamic and kinetic de-scriptors for the hydrogenation of ketones by molecular catalysts. Two complexes with known hydricity, HRh(dmpe)2 and HCo(dmpe)2, were investigated for the catalytic hydrogenation of ketones under mild conditions (1.5 atm, 25 °C). The rho-dium catalyst proved to be an efficient catalyst for a wide range of ketones, whereas the cobalt catalyst could only hydrogenate electron-deficient ketones. Using a combination of experiment and electronic structure theory, thermodynamic hydricity val-ues were established for 46 alkoxide/ketone pairs in both MeCN and THF solvent. Through comparison of the hydricities of the catalysts and substrates, it was determined that catalysis was only observed for catalyst/ketone pairs with an exergonic H- transfer step. Mechanistic studies revealed that H- transfer was rate-limiting step for catalysis, allowing for the experi-mental and computation construction of linear free-energy relationships (LFERs) for H- transfer. Further analysis revealed the LFERs could be reproduced using Marcus theory, in which the H- self-exchange rates for the HRh/Rh+ and ketone/alkoxide pairs were used to predict the experimentally measured catalytic barriers within 2 kcal mol-1. These studies significantly expand the scope of catalytic reactions that can be analyzed with a thermodynamic hydricity descriptor and firmly establish Marcus theory as a valid approach to develop kinetic descriptors for designing catalysts for H- transfer reactions.