Researchers at PNNL are pursuing new approaches to understand, predict and control the phenome—the collection of biological traits within an organism shaped by its genes and interactions with the environment.

By combining computational modeling with experimental research, scientists identified a promising composition that reduces the need for a critical material in an alloy that can withstand extreme environments.

Researchers developed a robust, cost-effective, and easy-to-use cap-based technique for spatial proteome mapping, addressing the lack of accessible proteomics technologies for studying tissue heterogeneity and microenvironments.

PNNL researchers have developed a new, physics-informed machine learning model that accurately predicts how heat accumulates and dissipates during friction stir processing.

Ljiljana Paša-Tolić, a PNNL fellow, is the recipient of the 2024 International Mass Spectrometry Foundation’s Jochen Franzen Award. 

PNNL contributes to a nationwide research consortium investigating the molecular mechanisms triggered by endurance training.

Senior Advisor Isabella van Rooyen shares her journey from child to internationally recognized scientist in nuclear materials and manufacturing.

PNNL scientists took thousands of measurements of firefighters in training to learn more about how the body responds to vigorous exercise.

This study profiled the 24-hour rhythmicity in bile salt hydrolase enzyme activity using simple fluorescence assay and the results showed that this rhythmicity is influenced by feeding patterns of the host.

Joshua Adkins and Jamie Lo will lead PMedIC, Pacific Northwest National Laboratory and Oregon Health & Science University’s joint research institute.

New research from PNNL and Washington State University collaborators connects the microbiome in the gut to circadian rhythms, suggesting a role for the microbiome as an internal regulator.

Advanced proteomic analysis tools dig deep into human blood plasma to understand the molecular nature of advanced alcoholic disease.

PNNL Biomedical Scientist Geremy Clair has taken on new roles as an editor for two journals; Frontiers In Cellular And Infection Microbiology and Frontiers In Molecular Biosciences.

Study highlights microbiome’s role in regulating xenobiotic metabolism.

The nested nanoPOTS chip is the next generation of technology developed at PNNL to prepare single cells for proteomics.

Customized molecular tools identify specific microbial functions that are key to healthy people and environments.

Rotational Hammer Riveting, developed by PNNL, joins dissimilar materials quickly without preheating rivets. The friction-based riveting enables use of lightweight magnesium rivets and also works on aluminum and speeds manufacturing.

Twelve energy-related technologies developed at PNNL have been selected for additional technology maturation funding to help move them from the laboratory and field tests to the marketplace.

Superman may be known as the "Man of Steel," but scientific superheroes at the Department of Energy's Pacific Northwest National Laboratory are developing a novel approach for manufacturing metals with superior strength.

A PNNL study that evaluated the use of friction stir technology on stainless steel has shown that the steel resists erosion more than three times that of its unprocessed counterpart.