Two Dimensional Meta-Material Windows
We have developed a novel 2D meta-material film that is designed to gather light from any direction perpendicular to the active direction and direct it along a path set by the design of the meta-material. We expect that these simple films may be used in a crossed geometry to provide light direction from any angle. These meta-materials are designed to work in the visible wavelengths and may be used as passive light gathering films for solar power devices or daylighting applications. These films would supplant bulky and expensive mirrored shelves or active solar tracking devices.
Methods for associating or dissociating guest materials with a metal organic framework, systems for associating or dissociating guest materials within a series of metal organic frameworks, and gas separation assemblies
Methods for releasing associated guest materials from a metal organic framework are provided. Methods for associating guest materials with a metal organic framework are also provided. Methods are provided for selectively associating or dissociating guest materials with a metal organic framework. Systems for associating or dissociating guest materials within a series of metal organic frameworks are provided. Gas separation assemblies are provided.
CAPTURE AND RELEASE OF ACID GASSES USING TUNABLE ORGANIC SOLVENTS WITH AMINOPYRIDINE
A class of water lean, organic solvents that can bind with various acid gasses to form acid gas bound molecules having a high degree of intramolecular hydrogen bonding which enables their use as regenerable solvents for acid gas capture. Unlike the other devices described in the prior art, the present invention takes advantage of shortened distances between the portions of the molecule that form hydrogen bonds within the structures when loaded with an acid gas so as to create a molecule with a higher internal bonding affinity and a reduced proclivity for agglomeration with other molecules.
CAPTURE AND RELEASE OF ACID GASSES USING TUNABLE ORGANIC SOLVENTS WITH AMINOPYRIDINE
A class of water lean, organic solvents that can bind with various acid gasses to form acid gas bound molecules having a high degree of intramolecular hydrogen bonding which enables their use as regenerable solvents for acid gas capture. Unlike the other devices described in the prior art, the present invention takes advantage of shortened distances between the portions of the molecule that form hydrogen bonds within the structures when loaded with an acid gas so as to create a molecule with a higher internal bonding affinity and a reduced proclivity for agglomeration with other molecules.
DIRECT DETERMINATION OF ANTIBODY CHAIN PAIRING
I have developed a tandem mass spectrometry (MS/MS) based approach for the direct determination of antibody heavy and light chain pairing. This approach eliminates the need for costly and invasive genomics approaches (e.g. B cell sequencing and hybridoma) for determining heavy and light chain pairing during therapeutic antibody discovery. IgG antibodies are composed of two copies of a light chain and two copies of a heavy chain covalently linked by intermolecular disulfide bonds. I have demonstrated that ultraviolet photodissociation (UVPD) and electron capture dissociation (ECD) can efficiently cleave the intermolecular disulfide bonds that bind the heavy and light chains together. This yields a MS/MS spectrum that contains the mass of the intact antibody or Fab fragment, intact mass of the light chain, intact mass of the heavy chain or Fd subunit, and product ions that provide confirmation of the (complementarity determining regions) CDR sequences. This information provides unambiguous confirmation of heavy and light chain pairing. These are completely unprecedented results and will have significant impact on therapeutic antibody discovery as well as quality control during production of antibody therapeutics.
SEPARATOR ASSEMBLIES AND METHODS (iEdison No. 0685901-18-0025)
Here we disclose a device that filters large particles out of a mixture of particles of multiple sizes without the addition of "clean" liquid streams. Using the device in a cascade pair produces a stream of particles with a narrow and well defined particle distribution of large particles. The distinguishing features include separation without any moving parts, without the addition of a mass separating agent, and without the addition of energy (other than the energy provided by an external pump to drive fluid flow). Further distinguishing features include but are not limited to operation at Reynolds numbers high enough to be turbulent in configurations commensurate with pipe flow with a unique express lane structure. No clean (particle free stream) is necessary because the device takes one mixed input stream and provides two separated outlet streams, one of which has the large particles of interest. Cascades and arrays of the device may be used to tune the output for desired applications.
PROSTATE CANCER-ASSOCIATED SECRETED PROTEINS (NIH iEdison No. 0685901-16-0007)
Methods are provided for treating a subject with prostate cancer and/or diagnosing a subject at risk for prostate cancer, which can include measuring increased expression of at least two prostate cancer-related molecules in a sample obtained from a subject, including the prostate cancer-related molecules AGR2, AGR3, CRISP3, CCL3, CEACAM5, CEACAM6, IL24, MMP9, CXCL14, CD90, POSTN, and SFRP4. The methods can include administering at therapy to a subject with prostate cancer. Methods are provided for treating a subject with intermediate- or high-risk prostate cancer, which can include measuring increased expression of MMP9 in a sample obtained from a subject compared to a control representing expression of MMP9 expected in a sample from a subject who has low-risk prostate cancer.
ORGANISM MONITORING DEVICES AND ORGANISM MONITORING METHODS
This application is related to U.S. Patent No. 10,236,920, issued on March 19, 2019, entitled "Signal Transmitter and Methods for Transmitting Signals from Animals". Multiple versions of the new RF transmitter have been designed to address the research needs for the three main bat species (hoary, eastern red and silver-haired bats) that are most frequently killed by wind turbines. Option A will focus on minimizing the transmitter size and weight to study the endangered species of Myotis that could be too small to use the current RF transmitters commercially available. Option B will prioritize service life over the transmitter size, weight, and detection range. This option targets the tracking applications for studying the migratory behavior of hoary, eastern red and silver-haired bats, while still staying under the 5% tag-burden guideline. Option C will have the longest detection range of the three while keeping the transmitter size and weight reasonable. This long-range version of the transmitter will be suitable for studying the potential landscape scale attraction of bats to wind turbines, as well as their fine-scale movements across one or more wind farms. It is also useful for tracking for other wildlife such as birds and aquatic species such as fish.
CAPTURE AND RELEASE OF ACID GASSES USING TUNABLE ORGANIC SOLVENTS WITH BINDING ORGANIC LIQUIDS
A class of water lean, organic solvents that can bind with various acid gasses to form acid gas bound molecules having a high degree of intramolecular hydrogen bonding which enables their use as regenerable solvents for acid gas capture. Unlike the other devices described in the prior art, the present invention takes advantage of shortened distances between the portions of the molecule that form hydrogen bonds within the structures when loaded with an acid gas so as to create a molecule with a higher internal bonding affinity and a reduced proclivity for agglomeration with other molecules.
CONTROLLED SYNTHESIS OF HIERARCHICALLY-STRUCTURED HYBRID MATERIALS THROUGH PEPTOID ENGINEERING
In nature, specific biomolecules interacting with mineral precurors are responsible for the precise production of nanostructured inorganic materials that exhibit complex morphologies and superior performance. Despite advances in developing biomimetic approaches, the design rules for creating sequence-defined molecules that lead to the synthesis of inorganic nanomaterials with predictable complex morphologies are unknown. To address this challenge, this patent application highlights a new peptoid-based biomimetic approach for controlled synthesis of hierarchically-structured metallic nanomaterials. Though the detailed investigation of some peptoid-controlled gold nanomaterial formation processes by engineering peptoid sequences and investigating the resulting particle formation mechanisms, we develop a rule of thumb for designing peptoids that predictively enabled the morphological evolution from spherical to coral-shaped nanoparticles. These individual coral-shaped gold nanoparticles exhibit a plasmonic enhancement as high as 105 fold. This research presented in this patent application significantly advances our ultimate vision of predictive bio-inspired materials synthesis using sequence-defined synthetic molecules that mimic proteins and peptides.