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Fundamental and Computational Sciences Directorate

Staff information

Rosey Chu

Biosystms Dynamics & Simula
Pacific Northwest National Laboratory
PO Box 999
MSIN: K8-98
Richland, WA 99352

PNNL Publications


  • Blair SL, AC Macmillan, GT Drozd, AH Goldstein, RK Chu, L Pasa Tolic, JB Shaw, N Tolic, P Lin, J Laskin, A Laskin, and S Nizkorodov. 2017. "Molecular Characterization of Organosulfur Compounds in Biodiesel and Diesel Fuel Secondary Organic Aerosol." Environmental Science & Technology 51(1):119-127.  doi:10.1021/acs.est.6b03304
  • Chen H, RC Johnston, BF Mann, RK Chu, N Tolic, JM Parks, and B Gu. 2017. "Identification of Mercury and Dissolved Organic Matter Complexes Using Ultrahigh Resolution Mass Spectrometry." Environmental Science & Technology Letters 4(2):59-65.  doi:10.1021/acs.estlett.6b00460
  • Dohnalkova A, MM Tfaily, AP Smith, RK Chu, AR Crump, CJ Brislawn, T Varga, Z Shi, L Thomashow, JB Harsh, and CK Keller. 2017. "Molecular and Microscopic Insights into the Formation of Soil Organic Matter in a Red Pine Rhizosphere." Soils 1(1):Article No. 4.  doi:10.3390/soils1010004
  • Nguyen SN, AV Liyu, RK Chu, CR Anderton, and J Laskin. 2017. "Constant-Distance Mode Nanospray Desorption Electrospray Ionization Mass Spectrometry Imaging of Biological Samples of Complex Topography." Analytical Chemistry 89(2):1131-1137.  doi:10.1021/acs.analchem.6b03293
  • Staley C, AP Ferrieri, MM Tfaily, Y Cui, RK Chu, P Wang, JB Shaw, CK Ansong, HM Brewer, AD Norbeck, LM Markillie, FP do Amaral, T Tuleski, T Pellizzaro, BJ Agtuca, RA Ferrieri, S Tringe, L Pasa Tolic, G Stacey, and M Sadowsky. 2017. "Diurnal Cycling of Rhizosphere Bacterial Communities is Associated with Shifts in Carbon Metabolism." Microbiome 5:Article No. 65.  doi:10.1186/s40168-017-0287-1
  • Tfaily MM, RK Chu, JG Toyoda, N Tolic, EW Robinson, L Pasa Tolic, and NJ Hess. 2017. "Sequential extraction protocol for organic matter from soils and sediments using high resolution mass spectrometry." Analytica Chimica Acta 972:54-61.  doi:10.1016/j.aca.2017.03.031


  • Anderton CR, RK Chu, N Tolic, AV Creissen, and L Pasa-Tolic. 2016. "Utilizing a Robotic Sprayer for High Lateral and Mass Resolution MALDI FT-ICR MSI of Microbial Cultures." Journal of the American Society for Mass Spectrometry 27(3):556-559.  doi:10.1007/s13361-015-1324-6
  • Nakayasu ES, CD Nicora, AC Sims, KE Burnum-Johnson, YM Kim, JE Kyle, MM Matzke, AK Shukla, RK Chu, AA Schepmoes, JM Jacobs, R Baric, BJM Webb-Robertson, RD Smith, and TO Metz. 2016. "MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses." mSystems 1(3):e00043-16.  doi:10.1128/mSystems.00043-16
  • Pomraning KR, YM Kim, CD Nicora, RK Chu, EL Bredeweg, SO Purvine, D Hu, TO Metz, and SE Baker. 2016. "Multi-omics analysis reveals regulators of the response to nitrogen limitation in Yarrowia lipolytica." BMC Genomics 17(138):1-18.  doi:10.1186/s12864-016-2471-2
  • Stegen JC, AH Hurlbert, B Bond-Lamberty, X Chen, CG Anderson, RK Chu, F Dini-Andreote, SJ Fansler, NJ Hess, and MM Tfaily. 2016. "Aligning the Measurement of Microbial Diversity with Macroecological Theory." Frontiers in Microbiology 7:Article No. 1487.  doi:10.3389/fmicb.2016.01487
  • Stegen JC, JK Fredrickson, MJ Wilkins, A Konopka, WC Nelson, EV Arntzen, WB Chrisler, RK Chu, RE Danczak, SJ Fansler, DW Kennedy, CT Resch, and MM Tfaily. 2016. "Groundwater-Surface Water Mixing Shifts Ecological Assembly Processes and Stimulates Organic Carbon Turnover." Nature Communications 7:11237.  doi:10.1038/ncomms11237
  • Sun J, T Dutta, R Parthasarathi, KH Kim, N Tolic, RK Chu, NG Isern, JR Cort, BA Simmons, and S Singh. 2016. "Rapid room temperature solubilization and depolymerization of polymeric lignin at high loadings." Green Chemistry 18(22):6012-6020.  doi:10.1039/C6GC02258H


  • Duan J, VK Kodali, MJ Gaffrey, J Guo, RK Chu, DG Camp, II, RD Smith, BD Thrall, and W Qian. 2015. "Quantitative Profiling of Protein S-Glutathionylation Reveals Redox-Dependent Regulation of Macrophage Function During Nanoparticle-Induced Oxidative Stress." ACS Nano 10(1):524-538.  doi:10.1021/acsnano.5b05524
  • Kebaabetswe LP, AK Haick, MA Gritsenko, TL Fillmore, RK Chu, SO Purvine, BJM Webb-Robertson, MM Matzke, RD Smith, KM Waters, TO Metz, and TA Miura. 2015. "Proteomic Analysis Reveals Down-Regulation of Surfactant Protein B in Murine Type II Pneumocytes Infected with Influenza A Virus." Virology 438:96-107.  doi:10.1016/j.virol.2015.03.045
  • Mann BF, HM Chen, EM Herndon, RK Chu, N Tolic, E Portier, TR Chowdhury, EW Robinson, SJ Callister, SD Wullschleger, DE Graham, L Liang, and B Gu. 2015. "Indexing Permafrost Soil Organic Matter Degradation Using High-Resolution Mass Spectrometry." PLoS One 10(6):Article No. e0130557.  doi:10.1371/journal.pone.0130557
  • Tfaily MM, RK Chu, N Tolic, KM Roscioli, CR Anderton, L Pasa-Tolic, EW Robinson, and NJ Hess. 2015. "Advanced solvent based methods for molecular characterization of soil organic matter by high-resolution mass spectrometry." Analytical Chemistry 87(10):5206-5215.  doi:10.1021/acs.analchem.5b00116


  • Dang X, J Scotcher, S Wu, RK Chu, N Tolic, I Ntai, P Thomas, RT Fellers , BP Early, Y Zheng, KR Durbin, RD LeDuc, JJ Wolff, CJ Thompson, J Pan, J Han, JB Shaw, JP Salisbury, M Easterling, CH Borchers, JS Brodbelt, J Agar, L Pasa-Tolic, N Kelleher, and NL Young. 2014. "The first pilot project of the consortium for top-down proteomics: A status report." Proteomics 14(10):1130-1140.  doi:10.1002/pmic.201300438
  • Hyung SW, PD Piehowski, RJ Moore, DJ Orton, AA Schepmoes, TRW Clauss, RK Chu, TL Fillmore, HM Brewer, T Liu, R Zhao, and RD Smith. 2014. "Microscale Depletion of High Abundance Proteins in Human Biofluids using IgY14 Immunoaffinity Resin: Analysis of Human Plasma and Cerebrospinal Fluid." Analytical and Bioanalytical Chemistry 406(28):7117-7125.  doi:10.1007/s00216-014-8058-3
  • Su D, MJ Gaffrey, J Guo, KE Hatchell, RK Chu, TRW Clauss, JT Aldrich, S Wu, SO Purvine, DG Camp, II, RD Smith, BD Thrall, and W Qian. 2014. "Proteomic Identification and Quantification of S-glutathionylation in Mouse Macrophages Using Resin-Assisted Enrichment and Isobaric Labeling." Free Radical Biology & Medicine 67:460-470.  doi:10.1016/j.freeradbiomed.2013.12.004


  • Venceslau SS, JR Cort, ES Baker, RK Chu, EW Robinson, C Dahl, LM Saraiva, and IA Pereira. 2013. "Redox states of Desulfovibrio vulgaris DsrC, a key protein in dissimilatory sulfite reduction." Biochemical and Biophysical Research Communications 441(4):731-736.  doi:10.1016/j.bbrc.2013.10.116


  • Gao X, Q Zhang, D Meng, G Isaac, R Zhao, TL Fillmore, RK Chu, J Zhou, K Tang, Z Hu, RJ Moore, RD Smith, MG Katze, and TO Metz. 2012. "A reversed-phase capillary ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) method for comprehensive top-down/bottom-up lipid profiling." Analytical and Bioanalytical Chemistry 402(9):2923-2933. 

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