PNNL

Abstract

Mandatory nanotoxicology testing is just around the corner. Producers and users of nanomaterials that aren’t positioning themselves now for toxicity testing will find themselves scrambling to catch up when the first wave of regulations hits the industry. How should toxicology testing laboratories prepare themselves to meet the increased demand for testing and the unique testing protocols coming down the pipeline? And what capabilities should nanomaterial producers and users expect when they are using contracted toxicology labs to assess hazards? The traditional contract toxicology lab experienced in chemical toxicology is unlikely to have the right tools and expertise to deal with the unique challenges of nanomaterial toxicity testing. Because of their unique characteristics and behaviors, nanomaterials require testing approaches that are specific to these materials and, in many cases, still being developed. Specifically, labs must be equipped to characterize nanomaterials in multiple media and to generate and control exposures. Forward-looking labs also are preparing for emerging approaches in nanotoxicology testing and assays.