October 28, 2023

Species Extrapolation of Propyl Acetate Dose Metrics


We demonstrate the ability of the propyl PBPK model to predict dose metrics of propyl acetate, propanol, and propionic acid from a standard 90-day subchronic inhalation study of propyl acetate in male and female rats. The model was used to predict the same dose metrics in “reference” male and female humans using the same exposure conditions. Finally, we used reverse dosimetry with the model to predict what exposure conditions would lead to the same dose metrics measured in rats. These extrapolations of internal dose metrics based on known species differences in physiology and measured differences in metabolism offer a more scientific species extrapolation than conventional uncertainty approaches, potentially of interest for risk assessment.

Published: October 28, 2023


Smith J.N. 2021. Species Extrapolation of Propyl Acetate Dose Metrics Richland, WA: Pacific Northwest National Laboratory.