Recent studies have suggested that autocine signaling through epidermal growth factor receptor (EGFR) might be involved in generating or maintaining an intrinsic polarity in tissue cells, possibly via spatial localization of EGFR-mediated signaling. The difficulty of experimental investigation of autocrine signaling makes especially valuable an application of computational modeling for critical hypotheses about the dynamic operation of the underlying signaling circuits, both intracellular and extracellular. Toward this end, we develop and analyze here a spatially distributed dynamic computational model of autocrine EGFR signaling.
Revised: November 10, 2005 |
Published: January 31, 2004
Citation
Maly I.V., H.S. Wiley, and D.A. Lauffenburger. 2004.Self-Organization of Polarized Cell Signaling via Autocrine Circuits: Computational Model Analysis.Biophysical Journal 86, no. 1:10-22.PNNL-SA-40760.