October 9, 2021
Book Chapter

Proteomics for Bioforensics

Abstract

Proteomics is a useful tool for addressing numerous questions regarding any protein-containing sample. These questions can include indicators of production method or growth environment, such as whether a given organism is a wild or laboratory-adapted strain, or whether the growth medium used to culture a specific batch contains hydrolyzed milk casein or other components that can be used to narrow down the potential source of a given microbial sample. In addition, proteomics can address not only whether a protein toxin such as ricin is present in a given sample, but also collect information on other untargeted proteinaceous sample components, providing additional forensic context. This chapter briefly introduces proteomics methods and provides examples of bioforensic applications.

Published: October 9, 2021

Citation

Merkley E.D., B. Kaiser, D.S. Wunschel, and K.L. Wahl. 2020. "Proteomics for Bioforensics." In Microbial Forensics, edited by B. Budowle , S. Schutzer and S. Morse. 251-265. Cambridge, Massachusetts:Academic Press. PNNL-SA-138380. doi:10.1016/B978-0-12-815379-6.00017-9